摘要
目的采用静息功能磁共振成像低频振幅技术,通过观察双侧海马硬化(HS)颞叶癫痫(TLE)患者脑血氧水平依赖(BOLD)信号活动的改变,探讨TLE脑活动的神经机制。资料与方法采用低频振幅算法,对9例双侧HS的TLE患者及9名正常志愿者静息功能磁共振成像数据进行对比分析,观察TLE患者发作间期痫样放电时(IED)振荡幅度增高及降低的区域。结果TLE患者伴发IED时BOLD信号振荡幅度改变的区域基本呈双侧对称分布。振幅增加的区域包括:双侧海马、杏仁核、扣带回等边缘系统,双侧中央运动区、颞叶皮层,丘脑及中脑结构。振荡幅度降低的区域包括:扣带回前部(ACC)、内侧前额叶(MPFC)及顶下小叶(IPC)等经典缺省模式区域,而后扣带回(PCC)和楔前叶(Pcu)则未包含其中。结论低频振幅功能磁共振成像技术可以对癫痫引起脑的活动改变情况进行观察。振幅增高的脑区反映大脑对癫痫活动的产生、传播等易化作用,振幅降低区域反映了特定脑区功能的抑制,尤其是缺省模式功能的受抑制。这些改变反映了大脑易化与抑制两个系统对癫痫的脑功能进行调节。
Objective To study the amplitude of low-frequenct fluctuation（ALFF） of the resting-fMRI in the temporal lobe epilepsy （TLE） with bilateral hippocampal sclerosis （HS）, and to discussed its underlying nem＇o-pathophysiologieal mechanism. Materials and Methods The resting-fMRI data of 9 TLE patients with HS and 9 normal volunteers who per- formed ALFF were analysis. The amplitude of the blood oxygenation level-dependent （BOLD） activation of the resting-state brain was investigated. The brain structures having ALFF increase and decrease in TLE patients were demonstrated. Results The ALFF in TLE patients increased and decreased symmetrically in the brain regions. The increased involvement covered the limbic system such as hippocampi/amygdalae, cingulate gyrus;the neocortices such as primary motor cortices, temporal gyri ; the structures of midbrain and thalamus. The decreased involvement covered the regions of default mode such as anterior cingulated corte and medial prefrontal cortexventral, but posterior cingulated and precuneus not involved in this network. Conclusion The involvements of ALFF increase and decrease composed of excitatory and inhibitory systems in the TLE brain. The ALFF increase was considered as the facilitation such as the epileptic activity origination and propagation;while the ALFF decrease was suggested the function inhibition in these regions, especially implied the suspension in the default mode activity.
出处
《临床放射学杂志》
CSCD
北大核心
2009年第3期297-301,共5页
Journal of Clinical Radiology
基金
国家自然科学基金项目(30470510)
关键词
颞叶癫痫
海马硬化
低频振荡幅度
脑电功能磁共振同步联合
Temporal lobe epilepsy Hippocampal sclerosis Amplitude of low-frequent fluctuation Electroencepha- logram-functional MRI （EEG-fMRI）
