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Ⅰ类整合子与产ESBLs肺炎克雷伯菌多重耐药关系的研究 被引量：3

Identification of classⅠintegrons and multidrug resistance in ESBLs-producing Klebsiella pneumonia
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摘要 目的了解产ESBLs肺炎克雷伯菌的整合子存在状况。方法用PCR方法扩增I类整合酶基因,经电泳后检测扩增产物。结果72株产ESBLs肺炎克雷伯菌中检测出Ⅰ类整合子67株,检出率为93.0%,Ⅰ类整合子阳性菌对氨基糖苷类、喹诺酮类及头孢菌素类药物表现出较高的耐药,其多重耐药率明显高于I类整合子阴性菌株(P<0.05)。结论Ⅰ类整合子广泛地存在产ESBLs肺炎克雷伯菌中,Ⅰ类整合子对细菌多重耐药性的产生和传播起着重要作用。 Objective To investigate class Ⅰ integrons in ESBLs-producing Klebsiella pneumonia. Method Class Ⅰ integron gene was analyzed by PCR. Result Class Ⅰ integron gene was found in 93.0% of 72 strains of ESBLs-producing Klebsiella pneumonia. The positive strains of class Ⅰ integrons showed higher multidrug resistance to aminoglycosides and/or fluoroquinolones and/or cephalospofins than the negative strains of class Ⅰ integrons （ P 〈 0. 05 ）. Conclusion Class Ⅰ integrons were prevalent in ESBLs-produeing Klebsielta pneumonia and played an important role in the development and dissemination of muhidrug resistance.
作者 郑宇琼 陈淑贞 姚芬 蔡应木 钱元恕 林少微
机构地区 汕头大学医学院第一附属医院 汕头大学医学院
出处 《中国微生态学杂志》 CAS CSCD 2009年第2期116-117,共2页 Chinese Journal of Microecology
基金 2008年汕头市重点科技计划项目(汕府科[2008]85号)
关键词 肺炎克雷伯菌 ESBLS 整合子 多重耐药 Klebsiellapneumonia ESBLs Integrons Multidrug resistant
分类号 R446 [医药卫生—诊断学]
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参考文献8

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二级参考文献19

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共引文献38

同被引文献29

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引证文献3

二级引证文献23

中国微生态学杂志
2009年 第2期

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