摘要
目的评价思密达对功能性肠胀气的临床疗效及安全性，并探讨其治疗原理．方法采用随机分组、平行对照实验设计方法，观察功能性肠胀气患者６０例，在应用思密达和安慰剂治疗后症状积分、呼氢值及肠内气体量的改变．结果与安慰剂比较，思密达能够明显降低功能性肠胀气患者临床症状积分、肠内胀气指数及３ｈ呼氢值（０９±０２ｖｓ１９±０４，５９±２１ｖｓ１８４±８２，１６１±２４ｖｓ８４５±８７，Ｐ＜００１）．思密达治疗功能性肠胀气的总有效率为９００％，显著高于安慰剂的２３３％（χ２＝２６９３６，Ｐ＜００１）．思密达的主要副作用是便秘（６７％），但大多数患者能够耐受．结论思密达能够抑制肠内细菌酵解，减少肠内气体，改善临床症状，且安全性好．
AIM To evaluate the efficacy and safety of Smecta in treatment of overful gas in intestinal tract of patients with alimentray dyskinesia. METHODS By using a randomized and controlled clinical trial, the changes of symptom score, the amount of expiratory hydrogen H 2 and intestinal gas in 60 patients were observed before and after the treatment. The patients were divided into Smecta group ( n =30) and placebo group ( n =30). RESULTS Compared with placebo, Smecta could significantly decrease the symptom scores, the amount of expiratory hydrogen H 2, and the intestinal gas (0 9±0 2 vs 1 9±0 4,59±21 vs 184±82,16 1±2 4 vs 84 5±8 7, P <0 01). Total efficacy rate of Smecta and placebo were 90 0% and 23 3%, respectively, with a statistically significant difference between the two groups (χ 2=26 936, P <0 01). Side effect of Smecta was mainly constipation (6 7%), but most of the patients could endure. CONCLUSION Smecta can inhibit colonic fermentation of carbohydrates by intestinal bacteria, reduce the amount of intestinal gas and improve the symptoms caused by overful gas in alimentary tract.
关键词
功能性肠胀气
药物疗法
结肠疾病
思密达
腹泻
abdominal distension/drug therapy
Smecta/therapeutic use
colonic diseases, functional
dyspepsia
diarrhea
abdominal pain
