摘要
目的测定系统性红斑狼疮(systemic lupus erythematosus,SLE)患者血清补体C3、C4及免疫球蛋白水平,并进一步探讨它们与SLE临床表现及病情的相关性。方法采用散射比浊法测定92例SLE患者血清中补体C3、C4及免疫球蛋白水平。结果随着SLEDAI评分增加,血浆C3、C4水平逐渐降低,C4水平与病情活动成负相关,IgG水平略有增加;SLEDAI评分可有效表明治疗效果,激素使用量与补体C3、C4水平成反比,与IgG水平成正比,但无统计学差异;SLE的不同系统损害与血浆中C3、C4免疫球蛋白的表达水平无相关性。结论动态观察SLEDAI评分、C3、C4及免疫球蛋白的水平对SLE的病情活动度、治疗的选择及预后的判断有重要意义。
Objective To study the serum level of complement C3 , C4immunoglobulin in patients with systemic lupus erythematosus （SLE） and its possible relationship with lupus disease activity. Methods Serum concentration of complement C3 ,C4 and immunoglobulin of 92 cases with SLE were measured by Immunoturbidimetry （ITM）. Results With SLEDAI scores increasing, the plasma concentration of C3 and C4 decreased, serum level of immunoglobulin G incresed. There was significant difference of the serum level of C4 and SLE disease activity. SLEDAI should be helpful to estimate the therapeutic efficacy. The mean level of IgG was found to be higher in active SLE than in inactive SLE, but the difference was not statistically significant. There was not significant difference of the level of C3 ,Ca and immunoglobulin among different organ damage groups. Conclusion It is important to use the level of C3 ,C4 and immunoglobulin,SLEDAI scores to e- valuate the activity of SLE.
出处
《皮肤病与性病》
2009年第1期8-10,共3页
Dermatology and Venereology
