摘要
目的：观察补肾祛痰活血方对自然衰老和Ｄ－半乳糖（Ｄ－ｇａ１）所致衰老模型小鼠的学习记忆功能的影响。方法：采用避暗法和Ｍｏｒｉｓ水迷官法，研究补肾祛痰活血方对自然衰老和Ｄ－ｇａｌ衰老模型小鼠被动回避反射和空间分辨学习记忆能力的影响。结果：补肾祛痰活血方能增加Ｄ－ｇａ１衰老模型小鼠避暗实验潜伏期（Ｐ＜０．０５），减少其错误次数（Ｐ＜０．０５），并缩短其Ｍｏｒｉｓ迷官四个检测组合的潜伏期，还可明显增加自然衰老小鼠Ｍｏｒｉｓ迷官的Ｐ象限时间、穿环次数和游泳时间比（Ｐ＜０．０５），并缩短其潜伏期。结论：补肾祛痰活血方不但可改善衰老模型小鼠学习记忆能力而且可以减缓自然衰老小鼠学习记忆能力的减退，是一个较好的益智抗衰药物。
Objective:To observe the effect of the composite recipe of Invigoraling the kidney.eliminating the phlegm and promiting blood circulation(IEP) on the ability of learning and memories in senility model mice induced by age and D gal respectively.Methods:The tests of darkness avoidance response and Morris water maze paradigm were used to investigate respectively the ability of passive avoidance response and space identification in aged and senility model mice induced by D gal.Results:In senility mice induced by D gal,the incubation of darkness avoidance response was increased( P<0 05 ) and the error times was decreased( P<0 05 ) by IEP,while the incubation of four combination test in Morris water maze paradigm was shortened;In nature aged mice,the P quadrant time of Morris water maze paradigm as well as the crossing circle times and the ratio of swimming time was increased obviously,while the incubation period was shortened.Conclusions:The recipe(IEP) could improve the learning ability in senility model mice and delay the falling of the learning and memories ability in aged mice.Also,it could improve the learning ability of avoidance response and memory ability to identify the space direction in senility mice.The recipe (IEP) has proved to be a promising medicine for anti senility and be benefiting to the brain.
出处
《中国中医基础医学杂志》
CAS
CSCD
1998年第4期20-22,共3页
JOURNAL OF BASIC CHINESE MEDICINE
基金
国家中医药管理局科研基金
关键词
补肾祛痰活血
学习记忆
衰老
D-GAL
invigorating the Kidney、eliminating the phlegm and promoting blood circulation,ability of learning and memories,nature senility,D galactose.
