摘要
目的探讨复发性脑梗死患者血浆同型半胱氨酸水平特点,并对其相关因素进行分析。方法测定45例复发性脑梗死(RCI)、84例初发性脑梗死(FCI)患者的血浆同型半胱氨酸、三酰甘油、胆固醇、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平并进行分析。结果RCI组的同型半胱氨酸为17.70±7.57μmol/L,FCI组同型半胱氨酸为14.28±4.92μmol/L,差异有统计学意义(P<0.05);RCI组高同型半胱氨酸发生率(55.5%)高于FCI组(36.9%),差异有统计学意义(P<0.05)。高同型半胱氨酸与脑梗死复发相对危险度(OR)值为2.34,高血压、糖尿病、冠心病与脑梗死复发密切相关,OR值分别为3.64、2.34和2.58。结论除高血压、糖尿病、冠心病是脑梗死复发的传统危险因素外,高同型半胱氨酸是脑梗死复发的又一新的危险因素。
Objective To investigate plasma homocysteine level in patients with cerebral infarction and analyze the risk factors related to recurrent cerebral infaction. Methods homocysteine, triglyceride, total cholesterol, high density lipoprotein cholesterol （ HDL - C） and low density lipoprotein cholesterol（ LDL - C） were measured in 45 cases with recurrent cerebral infarction （RCI） and 84 eases with first cerebral infarction （FCI）. The level of homocysteine of patients and its related factors were analyzed. Results The level of homocysteine in RCI group was （ 17.70 ±7.57） μmol/L, significantly higher than that in FCI group （ 14.28 μ4.92 μmol/L, P 〈 0.05）. The significant differences of the percentage of hyperhomocysteinemia were also observed between RCI group and FCI group （55.5% vs 36.9%, P 〈 0.05 ）. The odds ratio （OR） in RCI group was 2.34, the recurrent cerebral infarction was associated with hypertension （ OR 3.64）, diabetes mellitua （ OR 2.34 ） and coronary atherosclerotic heart disease （ OR 2.58）. Conclusion High level of homocysteine is a new risk factor that is associated with recurrent cerebra infarction.
出处
《临床和实验医学杂志》
2009年第3期7-8,共2页
Journal of Clinical and Experimental Medicine
关键词
脑梗死
复发
同型半胱氨酸
危险因素
Homocysteine
Cerebral infarction
Recurrence
Risk factor
