摘要
目的探讨口服丙基硫氧嘧啶联合甲状腺局部注射地塞米松治疗儿童甲状腺功能亢进(简称甲亢)的临床疗效。方法46例儿童甲亢患者随机分为两组,治疗组(n=20)口服丙基硫氧嘧啶联合地塞米松甲状腺局部注射,对照组(n=26)仅口服丙基硫氧嘧啶。结果临床症状缓解所需时间治疗组为(3.85±1.18)周,对照组为(4.1±0.99)周,治疗组症状缓解时间较对照组明显缩短(P<0.05);游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)恢复正常所需时间治疗组为(5.0±1.30)周,对照组为(5.5±1.36)周,治疗组所需时间较对照组明显缩短(P<0.05);两组均未见明显不良反应。结论口服丙基硫氧嘧啶联合地塞米松甲状腺局部注射治疗儿童甲亢较单纯口服丙基硫氧嘧啶能够更快地控制病情,安全可靠。
Objective To observe the efficacy of topical injection of dexamethasone combined with oral propylthiouracil in the treatment of children hyperthyroidism. Methods 46 children with hyperthyroidism were randomly divided into two groups, Children in treatment group were treated with oral propylthiouracil combined with topical injection of dexamethasone while children in control group were treated with oral propylthiouracil only. Results The time for remission of clinical symptoms and for recovery to normalization of FT3 and FT4were significantly reduced in treatment group than in control group [（3.85± 1.18） vs （4.1 ±0.99） weeks and （5.0 ± 1.30） vs （5.5 ± 1.36） weeks]. There were no severe adverse effects or complications in both groups. Conclusion The treatment of oral propylthiouracil combined with topical injection of dexamethasone in children with hyperthyroidism is more effective than oral propylthiouracil only and it is safe.
出处
《世界临床药物》
CAS
2008年第11期666-669,共4页
World Clinical Drug
