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他汀类对慢性稳定性心绞痛患者预防心房颤动的疗效观察

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摘要 目的探讨他汀类对慢性稳定性心绞痛患者预防心房颤动(房颤)发生的作用。方法选择事先无心房颤动的549例慢性稳定性心绞痛患者进行队列研究,分成治疗组(长期服用他汀类药物)和对照组,随访5年,主要观察两组房颤发生率。结果75例(13.7%)发生了心房颤动。治疗组发生房颤29例(10.1%)明显低于对照组46例(17.9%)。男性与女性房颤发生率分别为17例(10.24%)和12例(10.00%),组间比较差异无统计学意义(>0.05)。两组治疗后左房大小及心功能变化差异无统计学意义(>0.05),治疗组C反应蛋白(CRP)水平明显降低(<0.01)。结论使用他汀类的患者心房颤动发生明显减少,可能涉及阻止冠状动脉疾病进展效应和其他多种效应如他汀类对CRP、炎症或自主神经系统的作用。
作者 岑镇波 盛益 郑易
机构地区 浙江省慈溪市人民医院
出处 《现代实用医学》 2009年第2期138-139,共2页 Modern Practical Medicine
关键词 心绞痛 心房颤动 药物疗法 抗心律失常药
分类号 R541.75 [医药卫生—心血管疾病] R972.2 [医药卫生—药品]
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参考文献8

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现代实用医学
2009年 第2期

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