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X连锁凋亡抑制蛋白在膀胱癌的表达及其意义

Expression and significance of X-linked inhibitor of apoptosis protein in bladder cancer
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摘要 目的:探讨X连锁的凋亡抑制蛋白(XIAP)在膀胱移行细胞癌(BTCC)的表达情况,以及XIAP与BTCC病理分级、临床分期的关系。方法:收集临床上经病理确诊的BTCC手术标本62例,应用免疫组织化学测定肿瘤组织中XIAP的表达情况,将结果进行相关分析。结果:XIAP在膀胱肿瘤中的阳性表达率为67.7%,在正常膀胱移行上皮阳性表达率为23.1%,两者差异有统计学意义(P<0.005);在Ⅰ、Ⅱ、Ⅲ级BTCC的阳性表达率分别是75.0%、57.9%和66.7%,在浅表性和浸润性BTCC的阳性表达率分别为63.9%和73.1%,阳性表达率各组之间无统计学意义(P>0.05)。结论:XIAP可能在BTCC的发生、发展中发挥重要作用。 Objective:To study the expression of X-linked inhibitor of apoptosis protein (XIAP) in bladder transitional cell carcinoma (BTCC) and to clarify the relationship between the pathological grades and clinical stages of BTCC. Methods: The epithelium speeiment of 62 cases of BTCC confirmed by pathological method were collected and the expression of XIAP was detected by using immunohistochemical assay( SP methods). Results:The positive expression rate of XIAP in BTCC was 67.7% ,which was significantly higher than that of normal bladder tissues (23.1% ) (P 〈 0.005 ). The positive expression rates in grade Ⅰ , Ⅱ and Ⅲ were 75.0% , 57.9% and 66.7% , respectively; The positive expression rates in stage Ta-T1 and T2-T4 were 63.9% and 73. 1% , respectively. Conclusions :It is suggested that high expression of XIAP may play an important role in the mechanisms of tumorignesis and development of BTCC,
出处 《蚌埠医学院学报》 CAS 2009年第3期229-231,共3页 Journal of Bengbu Medical College
关键词 膀胱肿瘤 移行细胞 免疫组织化学 X连锁凋亡抑制蛋白 bladder neoplasms carcinoma,transitional eell immunohistochemistry X-linked inhibitor of apoptosis protein
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参考文献11

  • 1Holcik M, Komeluk RG. XIAP. the guardian angel [J]. Nat Rev Mol Cell Biol,2001,2 ( 7 ) :550 - 556.
  • 2张友亭,程旭.自制丝裂霉素水凝胶剂预防膀胱肿瘤术后复发的临床观察[J].实用临床医药杂志,2007,11(4):80-80. 被引量:5
  • 3Vaux DL, I-Iaecker G, Strasser A. An evolutionary perspective on apoptosis [J]. Cell, 1994,76 (5) :777 - 779.
  • 4汪良,曾甫清,陈方敏,刘迎.转染XIAP基因对丝裂霉素诱导膀胱癌细胞凋亡的影响[J].临床泌尿外科杂志,2004,19(4):226-228. 被引量:5
  • 5Yang L, Cao Z, Yan H, et al. Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: implication for cancer specific therapy [ J ]. Cancer Res,2003,63 ( 20 ) : 6815 - 6824.
  • 6Sun C, Cai M, Gunasekera AH, et al. NMR structure and mutagenesis of the apoptosis protein XIAP[ J ]. Nature, 1999,401 (6 755) :818 -822.
  • 7Yang Y, Fang S, Jensen JP, et al. Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotie stimuli [J]. Science,2000,288 ( 5467 ) : 874 - 877.
  • 8Holcik M, Gibson H, Konleluk RG. XIAP: apoptotic brake and promising therapeutic target [J]. Apoptosis, 2001,6 (4) : 253 - 261.
  • 9Bilim V, Kasahara T, Hara N, et al. Role of XIAP in the malignant phenotype of transitional cell cancer ( TCC ) and therapeutic activity of XIAP antisense oligonucleotides against multidrugresistant TCC in vitro[ J]. Int J Cancer,2003,103 (1) :29 -37.
  • 10Krajewska M, Krajewski S, Banares S, et al. Elevated expression of inhibitor of apoptosis proteins in prostate cancer [ J ]. Clin Cancer Res ,2003,9( 13 ) :4914 - 4925.

二级参考文献20

  • 1Yang L, Cao Z, Yan H , et al. Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells : implication for cancer specific therapy [ J ] . Cancer Res, 2003, 63(20) : 6815 - 6824.
  • 2Ramp U, Krieg T, Caliskan E, et al. XIAP expression is an independent prognostic marker in clear-cell renal carcinomas [J]. Hum Pathol, 2004, 35(8) : 1022 - 1028.
  • 3Peter I., Natalie R , Katsuyukl T, et al. Suppression of apoptosis in mammalian cells by NAPI and a related family of IAP genes[J]. Nature, 1996, 379( 15) : 349 - 353.
  • 4Gruslin A, Qiu Q, Tsang BK. Influence of maternal smoking on trophoblast apoptosis throughout development : possible involvement of XIAP regulation [ J ]. Biol Reprod, 2001 , 65(4) : 1164 - 1169.
  • 5Li J, Feng Q, Kim JM, et al.Human ovarian cancer and cisplatin resistance : possible role of inhibitor of apoptosis proteins [ J ].Endocrinology,2001,142(1) : 370 - 380.
  • 6Ferreira CG, van der Valk P, Span SW, et al. Expression of X- linked inhibitor of apoptosis as a novel prognostic marker in radically resected non-small cell lung cancer patients [ J ].Clin Cancer Res, 2001 , 7 (8) : 2468 - 2674.
  • 7Hofmann HS, Simm A, Hammer A, et al. Expression of inhibitor of apoptosis proteins (IAP) in non-small cell human lung cancer [ J ]. J Cancer Res Clin Oncol, 2002, 128(10) : 554 - 560.
  • 8Lee YK, Bone ND, Strege AK, et al. VEGF Receptor phosphorylation status and apoptosis is modulated by a green tea component , epigallocatechin- 3 -gallate ( EGCG ) in B cell chronic lymphocytic leukemia [ J ]. Blood, 2004, 104 ( 3 ) : 788 - 794.
  • 9Runzhao Li, Huiping Pei, Takis Papas. The p42 variant of ETS1 protein rescues defective Fas-induced apop-tosis in colon carcinoma cells. Proc Natl Acad Sci U SA, 1999, 96:3876-3881.
  • 10John Silke, Christine J H, Paul G E, et al. The antiapoptotic activity of XIAP is retained upon mutation ofboth the caspase 3- and caspase 9-interacting sites. J Cell Biol, 2002, 157:115-124.

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