摘要
目的研究赭石水煎液的止血作用,探讨其可能的作用机理。方法毛细玻管法测定小鼠凝血时间(CT),小鼠断尾法测定小鼠出血时间(BT),同时进行血小板计数(PLC);全自动血液凝集仪测定大鼠凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT);采用酚试剂比色法测定大鼠血浆纤维蛋白原(Fg)含量。结果煅赭石高剂量水煎液能明显缩短BT和CT,生、煅赭石均能明显缩短PT、APTT、TT;生、煅赭石均能增加Fg含量,生品与煅制品之间无显著性差异。结论赭石具有促凝、止血作用,其作用机制可能是通过激活内、外源性凝血系统而止血。
Objective To study the hemostatic effect of ochre and to explore its mechanism. Methods High dose （12 g/ kg） and low dose （6 g/kg） of the aqueous extract from crude and calcined ochre were given to mice by gastric gavage for 5 days, and then the bleeding time （BT）, coagulation time （CT） and platelet count （PLC） as well as the prothrombin time （PT） and the activated partial thromboplastin time （APTT） and thrombin time （TT） were measured by the an- tomatic blood agglutination instrument. The content of fibrinogen （Fg） was detected by phenol reagent colorimetry. Re- suits The water decoction from high - dose calcined ochre could obviously reduce the BT and CT. The aqueous extract from both crude ochre and calcined ochre could reduce the PT, KPTT and TT. Meanwhile, both the crude ochre and calcined ochre could increased the content of Fg, but the difference was insignificant. Conclusion The ochre has hemostatic effect and its main hemostatic mechanism is related to the activation of the intrinsic and extrinsic blood coagulation system.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2009年第2期131-133,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
"十一五"国家科技支撑计划项目(2006BAI09B06-04)
关键词
赭石
止血
作用机制
Ochre
Hemostatic effect
Hemostatie mechanism
