摘要
目的探讨急性脑梗死患者血清白细胞介素-18（IL-18）的水平及临床意义。方法90例急性脑梗死患者按照神经功能缺损程度分为轻型组（29例）、中型组（37例）、重型组（24例），按病灶大小分为小病灶组、中病灶组、大病灶组，以同期健康体检者45例为对照组，观察各组间血清IL-18水平的差异及与病灶大小、病变程度的关系。结果大、中、小病灶组的血清IL-18水平分别为（288．4±59．3）、（237．5±58．0）、（186．9±50．6）ng／L，均明显高于对照组（147．2±42．8）ng／L（均P〈0．05），大病灶组的血清IL-18水平均高于中、小病灶组（均P〈0．05），中病灶组的血清IL-18水平高于小病灶组（P〈0．05）；重、中、轻型组的血清IL-18水平分别为（284．9±57．3）、（233．4±55．9）、（184．5±48．3）ng／L，均明显高于对照组（均P〈0．05），重型组的血清IL-18水平均高于中、轻型组（均P〈0．05），中型组的血清IL-18水平高于轻型组（P〈0．05）。结论血清IL-18水平与脑梗死的病情严重程度相关，IL—18可能参与了缺氧缺血性脑损伤的病理生理过程。
Objective To study the level and clinical significance of serum interleukin-18 （IL-18）in patients with acute cerebral infarction. Methods The level of serum IL-18 in patient with acute cerebral infarction（ n =90） and normal controls group （ n = 45） were detected by enzyme linked immunosorbent assay. Results The level of serum IL-18 in large,medium and small lesion group were（288.4 ±59. 3） ; （237.5 ±58. 0） ; （ 186.9 ±50. 6） ng/L respectively, which were significantly higher than those in normal control group. The level of serum IL-18 in control group was（ 147.2±42. 8） ng/L（P 〈0. 05）. large lesion group was significantly higher than that in medium and small lesion group （ P 〈 0. 05 ）. medium lesion group was significandy higher than that in small lesion group （ P 〈 0. 05）. The level of serum IL-18 in heavy,medium and light group were（284. 9 ±57.3） ; （233.4 ±55.9） ; （ 184. 5±48.3）ng/ L respectively, which were significantly higher than those in normal control group （P 〈 0. 05 ） ;heavy group was significandy higher than that in medium and light group（P 〈0. 05） ,medium group was significantly higher than that in light group（P 〈0. 05）. Conclusion The level of serum IL-18 was related to the severity of cerebral infarction,IL-18 may be involved in the pathogenesis of the hypoxic ischemic brain injury.
出处
《中国基层医药》
CAS
2009年第2期195-196,共2页
Chinese Journal of Primary Medicine and Pharmacy
