摘要
目的探讨重组人生长激素（rhGH）在老年患者肺部感染治疗中的应用价值。方法53例肺部感染老年患者随机分为观察组（25例）和对照组（28例），观察组应用小剂量rhGH（0．1U·Kg^-1·d^-1）于人院后第二天起每晚皮下注射，疗程10d；对照组给予等量的注射用水；两组其他治疗相同，包括抗感染、氧疗、营养支持等。观察两组疗效、治疗前后体重指数（BMI）、血清生长激素、胰岛素样生长因子-1、白蛋白、瘦素水平等变化情况。结果观察组总有效率88．0％，对照组为60．7％，两组比较差异有统计学意义（P〈0．05）；观察组治疗后体重指数、血清白蛋白、生长激素、胰岛素样生长因子-1、瘦素水平分别为：（26．1±4．1）kg／m^2、（38．4±6．6）g/L、（7．0±0．9）μg／L、（27．3±6．1）μg/L、（6．9±1．1）μg/L，与对照组治疗后的（21．8±3．4）kg／m^2、（29．5±5．1）g／L、（4．0±0．4）μg/L、（22．0±3．8）μg／L、（3．8±0．8）μg/L相比较，差异均有统计学意义（均P〈0．05）。结论重组人生长激素辅助治疗老年人肺部感染，能改善患者的营养状态，提高治疗效果。
Objective To investigate the adjunctive therapeutic effect of recombination growth hormone（ rh- GH） on the elderly patients with pulmonary infection. Methods 53 elderly patients with pulmonary infection were randomly divided into rhGH group（ n =25） and eontrol group（ n =28）. The rhGH group were received hypodermic injection of rHGH（0. 1 U·Kg^-1·d^-1） on the basement of standard therapy in every evening for 10 days. And the control group were received standard therapy. Clinical efficacy were compared between two groups. The level of albumin （ALB） , growth hormone（GH） , insulin-like growth faetor-1 （IGF-1）, leptin （LP） were measured and the body mass index（BMI） was observed in all cases before and after treatment. Results The overall efficacy of rhGH group and control group was 88.0% versus 60. 7%. The results showed significant statistical difference between both groups（ P 〈0. 05）. After treating with rhGH for 10 days,the level of BMI,ALB,GH,IGF-1 and LP were increased in the rhGH group, which were （ 26. 1 ± 4. 1 ） kg/m^2 ; （ 38.4 ± 6. 6） g/L; （ 7.0± 0. 9 ） μg/L; （ 27. 3 ±6. 1 ） μg/L; （ 6.9 ±1.1 ）μg/L respectively. And the level of BMI, ALB, GH, IGF-1 and LP were （ 21.8 ± 3.4 ） kg/m^2 ; （ 29.5 ±5. 1 ） g/L; （ 4. 0 ± 0. 4） μg/L; （22. 0 ±3.8） μg/L; （3.8 ±0. 8） μg/L in the control group after treatment. The results showed significant statistical difference between both groups （ P 〈 0. 05 ）. Conclusion There was obvious adjunctive therapeutic effeet of rhGH to the elderly patients with pulmonary infection by improving the nutritional state of these patients.
出处
《中国基层医药》
CAS
2009年第2期203-204,共2页
Chinese Journal of Primary Medicine and Pharmacy
