摘要
3-羟基丙腈与叠氮化铵(叠氮化钠与氯化铵反应获得)经1,3-偶极环化加成获得5-羟乙基四唑,在该合成过程中应用超声波技术,使收率提高至90.5%。5-羟乙基四唑与氯化亚砜经卤代反应得到5-氯乙基四唑,收率为77%;5-氯乙基四唑在碱性条件下经消除反应生成目标化合物5-乙烯基四唑,收率为70%。采用红外光谱、核磁共振、元素分析等对5-氯乙基四唑、5-乙烯基四唑进行结构表征。结果表明,所得产物为目标化合物。该法具有反应收率较高且稳定、易操作等优点。
Hydroxyethyltetrazole was synthesized by the 1,3-polar cycloaddition of 3-hydroxypropanenitrile and NH4N3 that produced by the reaction of NaN3 and NH4Cl. The ultrasonic technology was applied in this reaction and the yield was up to 90.5%. 5 Chloroethyltetrazole was prepared by the halogenation of hydroxyethyltetrazole and SO2Cl2 and the yield was 77%. 5-Vinyltetrazole was obtained by the elimination of 5-chloroethyhetrazole under the condition of alkaline, and the yield was 70%. 5 Chloroethyhetrazole and 5-vinyhetrazole were characterized by IR, ^1HNMR and elemental analyses. The results show that the final product was the target product. This method has the advantages of high and stable yield and convenient preparation.
出处
《火炸药学报》
EI
CAS
CSCD
北大核心
2009年第1期29-31,共3页
Chinese Journal of Explosives & Propellants
基金
青年创新基金项目(HZY01100-3)
