期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

吲哚胺2，3-二氧化酶和白细胞介素10在子痫前期患者胎盘组织中的表达 被引量：2

原文传递
导出
摘要 子痫前期是妊娠期特有的疾病，是孕产妇和围生儿死亡的主要原因，其确切机制不清，一般认为母胎免疫平衡失调和血管内皮受损是重要机制之一。近年来，国外学者发现，吲哚胺2，3-二氧化酶（indoleamine 2，3-dioxygenase，IDO）在维持母胎界面免疫平衡方面起重要作用，在IDO抑制物存在的条件下对胎儿的异体识别可导致补体活化、炎症及胎儿丢失。白细胞介素10（IL-10）对IDO的表达有抑制作用。
作者 赵芳 陈铎 吴燕菁 杨兰芝 辛虹
机构地区 河北医科大学第二医院产科
出处 《中华妇产科杂志》 CAS CSCD 北大核心 2009年第3期219-220,共2页 Chinese Journal of Obstetrics and Gynecology
基金 基金项目：河北省卫生厅科研基金（07226）
关键词 白细胞介素10 子痫前期 二氧化酶 吲哚胺 胎盘组织 OXYGENASE 免疫平衡 母胎界面
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献8

  • 1Caucheteux SM, Kanellopoulos-Langevin C, Ojcius DM. At the innate frontiers between mother and fetus: linking abortion with complement activation. Immunity, 2003,18 : 169-172.
  • 2Le Rond S, Gonzalez A, Gonzalez AS, et al. Indoleamine 2, 3 dioxygenase and human leucocyte antigen-G inhibit the T-cell alloproliferative response through two independent pathways. Immunology, 2005,116:297-307.
  • 3Honig A, Rieger L, Kapp M, et al. Indoleamine 2,3- dioxygenase (IDO) expression in invasive extravillous trophoblast supports role of the enzyme for materno-fetal tolerance. J Reprod Immunol, 2004,61:79-86.
  • 4Santoso DI, Rogers P, Wallace EM, et al. Localization of indoleamine 2,3-dioxygenase and 4-hydroxynonenal in normal and pre-eclamptic placentae. Placenta,2002,23 : 373-379.
  • 5Kudo Y, Boyd CAR, Sargent IL, et al. Decreased tryptophan catabolism by placental indoleamine 2, 3-dioxygenase in preeclampsia. Am J Obstet Gynecol, 2003,188:719-726.
  • 6Lyall F, Simpson H, Bulmer JN, et al. Transforming growth factor-β expression in human placenta and placental bed in third trimester normal pregnancy, preeclampsia, and fetal growth restriction. Am J Pathol,2001, 159 : 1827-1838.
  • 7Tu H, Rady PL, Juelich T, et al. Cytokine regulation of tryptophan metabolism in the hypothalamic-pituitary-adrenal (HPA) axis: implications for protective and toxic consequences in neuroendocrine regulation.Cell Mol Neurobiol, 2005,25 : 673- 680.
  • 8Von Bubnoff D, Fimmersw R, Bogdanow M,et al. Asymptomatic atopy is associated with increased indoleamine 2,3-dioxygenase activity and interleukin-10 production during seasonal allergen exposure. Clin Exp Allergy, 2004,34 : 1056-1063.

同被引文献32

  • 1吕洁玉,杜二球,陈永利,胡平,金全芳,张冬霞.CD4^+CD25^+调节性T细胞在HBV宫内感染的表达及意义[J].郧阳医学院学报,2011,30(3):278-280. 被引量：6
  • 2Haiqi H,Yong Z,Yi L.Transcriptional regulation of Foxp3 in regula- tory T cells[J]. Immunobiology, 2011,216(6):678-685.
  • 3Liu G, Ma H, Qiu L,et al. Phenotypie and functional switch of macro- Phages induced by regulatory CD4~CD25~I' cells inmiee[J]. lmmunol Cell Biol,2011,89(1):130-142.
  • 4Turner MS,Kane LP,More PA.Dominant role of antigen dose in CD4~ Foxp3 regulatory t cell induction and expansion[J].j Immunol, 2009,183(8):4895-4903.
  • 5Wing K, Onishi Y, Prieto-Martin P, et aI.CTLA-4 control over Foxp3 regulatory T cell funetion[J].Science,2008,322:271-275.
  • 6AI-Buhtori M, Moore L, Benbow Ew, et al. Viral detection in hydrops fetalis, spontaneous abortion,and unexplained fetal death in utero[J].J Med Virol,2011,83(4):679-684.
  • 7解长银,臧晓娟,魏红,等.子痫前期患者胎盘组织及血浆中TGF-B1的表达及临床意义[J].中华临床医师杂志(电子版),2013,24(7):11427-11430.
  • 8Chappell LC, Enye S, Seed P, et al . Affverse pefinat~ outcomes and risk factors for preeelampsia in women with chronic hyperten- sion : a prospective study [J].Hypet'tension, 2008,51 ( 4 ) : 1002- 1009.
  • 9Laresgoiti-Servitje E. A leading role for the immune system in the pathophysiology of preeclampsia[J]. J Leukoc Biol, 2013,94 ( 2 ) : 247-257.
  • 10Sutton L, Mason DY, Redman CW. HLA-DR positive cells in the human placenta[ J]. Immunology, 1983,49 ( 1 ) : 103-112.

引证文献2

二级引证文献3

中华妇产科杂志
2009年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部