摘要
人类分娩发动的原因十分复杂,其中功能性孕激素撤退学说倍受关注。妊娠期间,高浓度孕激素维持子宫的静止状态,很多哺乳动物分娩时孕激素水平是下降的,但人类分娩发动时血中孕激素水平并不下降。目前认为,可能是孕激素受体表达异常导致孕激素功能下降。重点阐述孕激素核受体及膜受体的结构、亚型及表达,并对核受体及膜受体在分娩发动过程中的作用机制及其调节因素进行综述。
The mechanisms of onset of human parturition are very complicated, among which the concept of functional progesterone withdrawal has drawn more attention. High concentration of progesterone was required to maintain uterine quiescence throughout pregnancy. In contrast to most mammals, the levels of serum progesterone did not decline before the onset of labor in humans. Recent studies suggested that the functional decline of progesterone induced by the abnormal expression of progesterone receptor. This review focuses on the structure, subtype and expression of nuclear receptor and membrane receptor of progesterone, as well as the mechanisms and regulating factors of them during the onset of labor.
出处
《国际生殖健康／计划生育杂志》
CAS
2009年第2期114-117,共4页
Journal of International Reproductive Health/Family Planning
基金
卫生部科研基金(WKJ2007-3-001)
安徽省卫生厅临床医学应用技术研究(06B040)
关键词
功能性孕激素撤退
孕激素核受体
孕激素膜受体
分娩发动
Functional progesterone withdrawal
Progesterone nuclear receptor
Progesterone membrane receptor
Onset of labor
