期刊文献+

机械牵张力对成骨细胞及骨髓间充质干细胞的作用 被引量:6

The effects of mechanical tension on osteoblasts and bone marrow-derived mesenchymal stem cells
原文传递
导出
摘要 牵张成骨过程与通常的骨愈合过程有明显的不同,可以将其解读为牵张和成骨两个方面。骨髓间充质干细胞在一定的条件下可以分化为成骨细胞,而成骨细胞是骨改建的主要效应细胞。作用在两骨段的牵张力促进或激发了成骨细胞和骨髓间充质干细胞的增殖和分化从而实现骨的再生。近年来,关于牵张成骨过程中骨组织的超微结构变化的研究已经相对明了,在力学机制尚未完全明确。本文综述了牵张力对成骨细胞和骨髓间充质干细胞的增殖和分化方面的影响。 Compared with the normal process of bone healing, distraction osteogenesis is quite different. It is composed of distraction and osteogenesis. Osteoblasts are the main effect cells in bone formation, and bone marrow-derived mesenchymal stem cells (BMSCs) can differentiate into them under a certain degree of external stress. The mechanical tension applied to the two bone sections promotes or stimulates differentiation and proliferation of the osteoblasts and BMSCs, and then bone regeneration achieved. Recent years, many studies have clarified the alternation ofultrastructure of bone in the process of distraction osteogenesis. However, the mecha- nism is still unclear. In the review, the effects of mechanical tension on differentiation and proliferation of osteoblasts and bone marrow-derived mesenchymal stem cells were discussed.
作者 计宝辉 王杭
出处 《现代生物医学进展》 CAS 2009年第5期957-959,共3页 Progress in Modern Biomedicine
基金 国家自然科学基金(10702046)
关键词 牵张成骨 机械牵张力 成骨细胞 骨髓间充质干细胞 Distraction osteogenesis Mechanical tension Osteoblasts BMSCs
  • 相关文献

参考文献2

二级参考文献28

  • 1戚孟春,胡静,邹淑娟,韩力赤,罗恩.大鼠骨髓间充质干细胞和颅骨成骨细胞在张应力下细胞骨架的改变[J].华西口腔医学杂志,2005,23(2):110-112. 被引量:24
  • 2黎润光,邵景范,魏明发.机械牵张应力对成骨细胞的影响研究进展[J].中国矫形外科杂志,2006,14(6):457-460. 被引量:12
  • 3[1]Duncan RL, Turner CH. Mechanotransduction and the functional response of bone to mechanical strain[J]. Calcif Tissue Iht, 1995,57(5):344-358.
  • 4[2]Maniotis AJ, Chen CS, Ingber DE. Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure[J]. Proc Natl Acad Sci USA,1997, 94(3):849-854.
  • 5[3]Lum H, Malik AB. Regulation of vascular endothelial barrier function[J]. Am J Physiol, 1994, 267(3 Pt 1):L223-241.
  • 6[4]Janmey PA. The cytoskeleton and cell signaling: component localization and mechanical coupling[J]. Physiol Rev, 1998, 78: 763-781.
  • 7[7]Cillo JE Jr, Gassner R, Koepsel RR, et al. Growth factor and cytokine gene expression in mechanically strained human osteoblast-like cells: Implications for distraction osteogenesis[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2000, 90(2):147-154.
  • 8[8]Harter LV, Hruska KA, Duncan RL. Human osteoblast-like cells respond to mechanical strain with increased bone matrix protein production independent of hormonal regulation[J]. Endocrinology,1995,136(2): 528-535.
  • 9[9]Fong KD, Nacamuli RP, Loboa EG, et al. Equibiaxial tensile strain affects calvarial osteoblast biology [J]. J Craniofac Surg,2003,14(3): 348-355.
  • 10Wang H, Riha GM, Yan S, et aI.Shear stress induces endothelial differentiation from a murine embryonic mesenchymal progenitor cell line.Arterioscler Thromb Vasc Biol 2005;25(9): 1817-1823

共引文献26

同被引文献113

引证文献6

二级引证文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部