摘要
人工关节置换广泛用于终末期关节疾病的患者,以改善其生活质量。有部分关节置换患者的假体发生无菌性松动,目前认为,核激活因子受体配体-核激活因子受体-骨保护素-核因子-κB(RANKL-RANK-OPG-NF-κB)系统起着重要的作用。文中就RANKL-RANK-OPG-NF-κB系统如何调控假体周围骨溶解及骨溶解的药物干预进行综述。
Joint prosthesis is one of the most successful procedures in orthopaedic surgery and has considerably improved the quality of life for patients affected by terminal joint disease. However, a number of joint prosthesis ultimately failed because of aseptic loosening. There have been major advances in the understanding of aseptic loosening. The RANKL-RANK-OPG-NF-κB system has been shown to play a fundamental role in aseptic loosening. We review how the RANKL-RANK-OPG-NF-κB system regulates aseptic loosening and aseptic loosening drug intervention.
出处
《医学研究生学报》
CAS
2009年第3期320-323,共4页
Journal of Medical Postgraduates
基金
全军"十一五"重点攻关项目基金资助(批准号:06G043)
关键词
核激活因子受体配体
核激活因子受体
骨保护素
骨溶解
药物干预
Ligand of receptoractivator of nuclear factor-κB
Receptor activator of nuclear factor-κB
Osteopro tegerin
Osteolysis
Drug intervention
