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内抑素抗血管生成及抗类风湿性关节炎治疗 被引量：8

Endostatin:antiangiogenic properties and the therapeutic effect on rheumatoid arthritis
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摘要 血管生成是类风湿性关节炎(RA)早期滑膜病理改变特征之一,也是产生和维持RA血管翳的主要因素。内抑素可特异性抑制新生血管内皮细胞增殖、迁移、诱导其凋亡而发挥抗血管生成作用,应用内抑素抑制滑膜新生血管生成可成为治疗RA的一种全新方法。内抑素还可通过抑制成纤维样滑膜细胞增殖,促进其凋亡发挥抗RA效应。 Neovascularization is one of the early pathologic changes of rheumatoid arthritis（RA） synovium and is the major players in the promotion and perpetuation of pannus. Endostatin has antiangiogenie effect via inhibition of endothelial cell proliferation, migration and induction of apoptosis. The inhibition of angiogenesis in synovium by endostatin appears to be a promising means for the future treatment of RA. Also, endostatin has a therapeutic effect on RA by the inhibition of proliferation and induction of apoptosis in fibroblast-like synoviocytes.
作者 黄学应 陈飞虎 张晓明 刘永靖
机构地区 安徽医科大学药学院 安徽医科大学人体解剖学教研室 中国人民解放军
出处 《中国药理学通报》 CAS CSCD 北大核心 2009年第3期287-289,共3页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No30572196) 安徽省高等学校省级自然科学研究资助项目(NoKJ2007B034) 安徽省博士后科学基金资助项目(No07-08)
关键词 类风湿性关节炎 血管生成 内抑素 血管内皮生长因子 rheumatoid arthritis neovascularization endostatin vascular endothelial growth factor
分类号 R-05 [医药卫生] R329.24 [医药卫生—人体解剖和组织胚胎学]
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参考文献21

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二级参考文献53

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共引文献38

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二级引证文献72

中国药理学通报
2009年 第3期

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