摘要
目的:探讨无患子皂苷对原发性高血压大鼠的降压作用及对血管紧张素Ⅱ(AngⅡ)、醛固酮(Ald)和内皮素(ET)的影响。方法:采用原发性高血压大鼠模型,随机分为模型组、阳性药组(卡托普利)、无患子皂苷高、中、低3个剂量组,每组10只。每天给予各组大鼠相应药物灌胃给药1次,连续给药32 d。模型组以等量蒸馏水灌胃,分别于第1、3、7、32日每次的给药前及给药后1 h测定血压。末次给药后1 h,经腹主动脉取血,测定AngⅡ、Ald和ET的含量。结果:无患子皂苷给药降压作用明显;各给药组血浆中AngⅡ、Ald和ET浓度明显低于模型组(P<0.01);与模型组比,有显著性差异。结论:无患子皂苷具有降低原发性高血压鼠的血压作用,其作用机制可能与抑制血浆AngⅡ、Ald和ET水平有关。
AIM ： To observe the effects of sapindoside on blood pressure, Ang Ⅱ ,Ald, ET in the blood plasma and NO in the serum in primary hypertension rat. METHODS： The primary hypertension rats were divided into 5 groups（ high, middle and low sapindoside group, control group and captopril group, 10 each） in a random fashion and drugs had been given by ig. for 32 days. The blood pressure was messured in the 1,3,7,32 day after administration. At the end of the 32 nd days, Ang Ⅱ, Aid, ET in the blood plasma and NO in the serum were measured. RESULTS ： Sapindoside could significantly lower the blood pressure, increase the levels of NO in serum, reduce the concentration of Ang Ⅱ , Aid, ET in the blood plasma. CONCLUSION ： Sapindoside plays an important role in decreasing the blood pressure of primary hypertension rat.
出处
《中成药》
CAS
CSCD
北大核心
2009年第3期367-369,共3页
Chinese Traditional Patent Medicine
基金
安徽省教育厅自然科学基金项目(KJ2007B039)
