摘要
目的:以聚乙二醇6000(PEG)为基质制备姜黄素滴丸(固体分散体)和以淀粉为基质的姜黄素片相比较,研究基质对姜黄素在大鼠体内的药动学过程的影响。方法:SD大鼠分别灌胃,给予纯姜黄素、姜黄素片剂、姜黄素滴丸,HPLC法测定大鼠体内姜黄素的血药浓度,使用3P97软件计算药动学参数。结果:在大鼠体内药学过程符合单室模型,姜黄素滴丸与姜黄素相比Cmax、AUC显著增大,姜黄素滴丸对姜黄素的相对生物利用度为1 046%。结论:姜黄素滴丸能显著提高姜黄素在大鼠体内的生物利用度。
AIM： To compare curcumin dropping pill prepared from polyethylene glycol 6000 with curcumin tablet prepared from starch to study the effect of matrix on the pharmacokinetics of curcumin and in rats.METHODS： The rats fed with pure curcumin, curcumin tablet and curcumin dropping pill. The curcumin concentration of in whole blood was determined by HPLC. The data processing was completed by the software 3P97. RESULTS： The concentration-time curve of curcumin and curcumin dropping pill were fit to an one-compartment model. The total areas of curcumin dropping pill under the plasma concentration-time curve AUC were larger than that of pure curcumin. The relative bioavailability of curcumin dropping pill was 1 046% CONCLUSION ： The curcumin dropping pill could increase bioavailability of curcumin in rats of curcumin tablet in vivo remarkably.
出处
《中成药》
CAS
CSCD
北大核心
2009年第3期377-379,共3页
Chinese Traditional Patent Medicine
关键词
姜黄素
滴丸
固体分散体
药动学
生物利用度
大鼠
curcumin
dropping pill
solid dispersion
pharmacokinetics
bioavailability
rat
