摘要
用手性固定相法拆分泮托拉唑钠对映体,并建立了检测泮托拉唑钠对映体光学纯度的HPLC方法。色谱柱为Chiralpak AD-H柱(250×4.6 mm,5μm),流动相为V(正己烷)∶V(异丙醇)=40∶60,流速为0.5 mL/min,检测波长为288 nm。该法可用于左旋泮托拉唑钠原料药和制剂的质量控制。
A chiral stationary phase HPLC method was established for separating the enantiomers of pantoprazole sodium and determining the content of the D-enantiomer. A Chiralpak AD-H column（250 mm× 4.6 mm, 5 μm）was used with the mobile phase of n-hexane/isopropanol （40/60, V/V）. The detection wavelength was set at 288 nm and the flow rate was 0.5 mL/min. The present study provides a simple and reproducible method for the enantiomeric quality control of L-pantoprazole sodium.
出处
《分析试验室》
CAS
CSCD
北大核心
2009年第4期67-69,共3页
Chinese Journal of Analysis Laboratory
基金
辽宁省教育厅基金(20060362)项目资助
