期刊文献+

表面肝素改性TLM钛合金的血液相容性评价(英文) 被引量:12

Evaluation of Haemocompatibility of TLM Titanium Alloy with Surface Heparinization
下载PDF
导出
摘要 在新型近β钛合金TLM(Ti-3Zr-2Sn-3Mo-25Nb)表面用溶胶-凝胶法镀上一层TiO2薄膜,再将薄膜依次用羟基化溶液和胺基化溶液处理以在薄膜表面引入活性OH-和NH2-,然后通过该活性官能团将肝素共价键接在薄膜表面。利用XRD、SEM和EDS研究了TiO2薄膜的相结构和表面特性;通过测定材料表面的接触角、溶血率和血小板黏附行为对肝素化TLM合金的血液相容性进行分析、评价。结果表明,表面肝素化处理后TLM合金的血液相容性得到了明显的改善。 A layer of TiO2 film was prepared by sol-gel method on the surface of TLM(Ti-3Zr-2Sn-3Mo-25Nb) alloy. Then the coated samples were treated by hydroxyl solution and amination solution in order to introduce the OH and NH2 active groups, and the heparin was linked on the surface of TiO2 film through these active groups. The phase identification and the surface characteristics of the samples were successively undertaken using XRD, SEM and EDS. The in vitro blood compatibility of the TLM alloy specimens with and without heparinization treatments was evaluated by the contact angle test, the hemolysis test and investigation of their platelet adhesion behavior. The results showed that the haemocompatibility of the TLM alloy could be significantly improved by surface modification via heparinization.
出处 《稀有金属材料与工程》 SCIE EI CAS CSCD 北大核心 2009年第3期384-388,共5页 Rare Metal Materials and Engineering
基金 Key Foundation Research Project of China(2005CB623904) National Natural Science Foundation of China(30770586)
关键词 血液相容性 肝素化 TLM合金 薄膜 表面改性 haemocompatibility heparinization TLM alloy film surface modification
  • 相关文献

参考文献17

  • 1Wise D Let al. Biomaterials and Bioengineering Handbook[M]. New York: Marcel Dekker Inc, 2000:205.
  • 2Jing Fengjuan et al. Materials Review[J], 2003, 17:187.
  • 3Brynda E et al. Biomed Mater Res[J], 2000, 2:249.
  • 4Yang Ping et al. Surface and Coatings Technology[J], 2002, 156: 284.
  • 5Michanetzis G PA et al. Biomaterials[J], 2003, 24:677.
  • 6Yu Zhentao et al. Materials Science and Engineering A[J], 2006, A438-440:391.
  • 7张明华,于振涛,周廉,张殿忠.β型钛合金材料的生物相容性评价[J].稀有金属材料与工程,2007,36(10):1815-1819. 被引量:5
  • 8YuZhentao(于振涛)etal.稀有金属材料与工程,2006,35:261-261.
  • 9刘敬肖,杨大智,史非,蔡英骥,陈吉华,王伟强,孔力,胡军,杨佩满.金属表面TiO_2薄膜的溶胶-凝胶法制备及其血液相容性研究[J].中国生物医学工程学报,2002,21(5):398-403. 被引量:21
  • 10Harizanovl O et al. Solar Energy Materials & Solar Cells[J], 2000, 63:185.

二级参考文献16

  • 1许智轩,张玉梅,王忠义,于振涛,周廉,赵彦涛.医用新型钛合金的口腔刺激试验[J].稀有金属材料与工程,2006,35(1):110-113. 被引量:11
  • 2许智轩,张玉梅,王忠义,于振涛,周廉,赵彦涛.两种新型医用钛合金的皮肤致敏试验[J].实用口腔医学杂志,2006,22(3):350-352. 被引量:4
  • 3尹光福 王昌祥 等.新型人工关节替换材料血液相容性评价[J].功能材料,1998,10:925-925.
  • 4浦素云 吴云书.植入金属材料在人体环境中腐蚀行为的研究[J].中国生物医学工程学报,1988,7(3):125-125.
  • 5[1]Huang Nan,Yang Ping, Cheng Xuan, Leng Yongxiang, et al.[J]. Biomaterials, 1998, 19:771-776.
  • 6[2]Huang N, Yang P, Leng Y X. et al. [J]. Biomaterials, 2003,24: 2177-2187.
  • 7[3]Yang P, Huang N, Leng Y X. et al. [J]. Surface and Coatings Technology, 2002, 156: 284-288.
  • 8[4]Nicolas Martin, Christophe Rousselot, Daniel Rondor, et al.[J]. Thin Solid Films, 1997, 300:11.
  • 9ZhangYumei(张玉梅) GuoTianwen(郭天文) LiZuochen(李佐臣).生物医学工程杂志,2000,17(2):206-206.
  • 10Toshihiro Kasuga, Masayuki Nogami, Mitsuo Niinomi et al. Biomaterials [J], 2003, 24(2): 283

共引文献29

同被引文献44

  • 1武芸,丁莉,周吉源.五鹤续断中铅、镉、汞重金属元素含量分析[J].湖北民族学院学报(医学版),2005,22(2):12-14. 被引量:5
  • 2史嘉玮,董念国.RGD肽在组织工程领域的应用[J].中华实验外科杂志,2005,22(9):1150-1152. 被引量:19
  • 3陈俊英,万国江,冷永祥,杨萍,孙鸿,王进,黄楠,陈槐卿,唐戎.Ti-O薄膜表面抗凝血及人脐静脉内皮细胞种植[J].中国科学(E辑),2005,35(11):1137-1144. 被引量:3
  • 4杨化娟,杨柯,张炳春.含La医用316L不锈钢的体外抗凝血性能研究[J].金属学报,2006,42(9):959-964. 被引量:12
  • 5魏艳萍,王潇婕,马晓洁,张玉梅.Ti_6Al_4V活性及耐磨涂层对成骨细胞生物学行为影响[J].临床口腔医学杂志,2006,22(10):587-589. 被引量:3
  • 6Ma W, Wei JH, Li YZ, et al. Histological evaluation and surface componential analysis of modified micro-- arc oxidation treated titanium implants [J]. J Biomed Mater Res B Appl Biomater, 2008, 86(1) : 162--169.
  • 7Ran W, Tian ZH, Guo B, et al. Superior biocompatibility and osteogenic efficacy of micro--arc oxidation--treated titanium implants in the canine mandible [J]. Biomed Mater, 2009, 4 (5) :4 055003.
  • 8Yao CH, Tsai HM, Chen YS, et al. Fabrication and evaluation of a new composite composed of tricalcium phosphate, gelatin, and Chinese medicine as a bone substitute [J], Biomed Mater Res Part B, 2005, 75(2) : 277--288.
  • 9Poh-Hui Chua, Koon-Gee Neoh, En-Tang Kang, et al. Surface functionalization of titanium with hyaluronic acid/chitosan polyelectrolyte multilaycrs and RGD for promoting osteoblast functions and inhibiting bacterial adhesion[J]. Biomaterials, 2008, 29(10): 1412-1421.
  • 10Yuqing Wan, Yong Wang, Zhimin Liu, et aL Adhesion and proliferation of OCT-1 ostenblast-like cells on micro- and nano-scale topography structured poly ( L-lactide ) [ J ]. Biomaterials, 2005, 26 (21) : 4453-4459.

引证文献12

二级引证文献29

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部