摘要
目的评价由羟基磷灰石(HA)/左旋聚乳酸(PLLA)复合研制的生物活性颈椎椎间融合器(BCFC)植入椎间后重建颈椎稳定性及抗最初脱位趋向。方法在6具颈椎标本上,前路颈5-6分别植入BCFC和髂骨,三维运动稳定性实验测量运动范围;颈4-5分别植入BCFC和髂骨,拔出力学实验测试最大拔出阻力。结果BCFC组在前屈、左右侧弯和左右轴向旋转的运动范围均较髂骨组减少,较髂骨组稳定,差异有统计学意义(P<0.005);在后伸状态下BCFC组和髂骨组较正常组运动范围增大,但差异无统计学意义(P>0.05)。BCFC的最大拔出阻力平均为117.87N(最小值97.5N,最大值135.1N)较骼骨的57.65N(最小值48.6N,最大值68.2N)大,抗脱位趋向较髂骨好,差异有统计学意义(P<0.01)。结论BCFC具有良好的生物力学性能,能重建颈椎稳定性,可满足颈椎椎间支撑融合的要求。
Objective To investigate the stability of cervical vertebrae interbody fusion and dislocation resistance with Bioactive Cervical Fusion Cage （BCFC） made of hydroxyapatite （HA） and poly L-lactic acid （PLLA） after anterior discectomy. Methods BCFC and iliac crest bone were used for anterior interbody implants after anterior discectomy across C5-C6 in six fresh human cervical spine specimens respectively,and the range of motion （ROM） of the cervical vertebrae interbody fusion were measured through the three dimensional motional stability test. BCFC and iliac crest bone were used for anterior interbody implants after anterior diseeetomy across C4-C5 respectively,and the resistance of BCFC and ifiac crest bone were measured through the pullout test. Results After discectomy,BCFC exhibited an decrease in angular motion than iliac crest bone and a significant increase in stability in flexion,left/right lateral bending and left/right axial rotation （P〈 0.005）. In extension,both BCFC and iliac crest bone were associated with a decrease in stability than the intact spine,but it was not significantly （P〉0.05）. BCFC required a median pullout resistance of 117.87N （minimum,97.5N;maximum, 135.1N） and iliac crest bone required a median pull- out resistance of 57.65N （minimum,48.6N;maximum,68.2N）,and BCFC exhibited a more excellent than iliac crest bone in preventing dislocation （P〈0.01）. Conclusion BCFC＇s biomcchanical perfor- mance was excellent and could remain or increase the immediate effects and initial stability of cervical vertebrae, and could perform the functions of cervical fusion.
出处
《颈腰痛杂志》
2009年第2期99-102,共4页
The Journal of Cervicodynia and Lumbodynia
基金
广东省自然科学基金重点攻关课题(2001A302020205)
关键词
羟基磷灰石类
聚乳酸类
生物相容性材料
颈椎椎间融合术
生物力学
hydroxyapatites
poly L-lactic acid
biocompatible materials
cervical vertebrae interbody fusion
biomechanics
