摘要
目的:探讨上皮性卵巢癌患者血清CA199水平与临床病理学特征的关系及其对预后的影响。方法:用电化学发光免疫分析法测定118例上皮性卵巢癌患者血清CA199、CA125水平,分析其与临床病理特征的关系及其对预后的影响。结果:非浆液性卵巢癌中血清CA199水平及阳性率高于浆液性卵巢癌(P<0.05);非浆液性卵巢癌中术前CA199水平阳性率Ⅲ期患者高于Ⅰ期和Ⅱ期患者(P<0.05),G1、G2级高于G3级(P<0.05),复发组高于未复发组(P<0.05);多因素分析表明临床分期和术前CA199水平对非浆液性卵巢癌预后有影响;用CA199升高预测复发的敏感性和特异性分别为50.00%和93.55%。结论:血清CA199对非浆液性卵巢癌的敏感性高于其对浆液性卵巢癌的敏感性,非浆液性卵巢癌患者术前CA199水平与其临床分期及病理分级密切相关,术后继续监测其水平对预测复发有一定的指导意义。
Objective：To study the effect of the serum level of CA199 on clinical and histological features in patients with epithelial ovarian carcinoma, and prognostic value thereof. Methods： The serum levels of CA199 and CA125 were measured using electrochemiluminescence immunoassay in 118 patients with epithelial ovarian carcinoma. The serum levels of CA199 and CA125, clinical features and prognostic value were carried out retrospectively. Results：The sensibility of CA199 in patients with nonserous epithelial ovarian carcinoma was much higher than that in serous epithelial ovarian carcinoma （P 〈 0.05）. In patients with nonserous epithelial ovarian carcinoma, the preoperative serum level of CA199 was more higher in stage Ⅲ patients than that of patients in stage Ⅰ and Ⅱ and much higher in patients of grade 1 and 2 than that in patients of grade 3 （P 〈 0.05）. The preoperative serum levels of CA199 were higher in recurrent patients than that in patients of unreeurrent group （P 〈 0.05）. The analysis of prognostic multi-factors showed that FIGO stage and the preoperative serum levels of CA199 were prognostic factors. The sensibility and specificity to predict recurrence using the increase level of serum CA199 were 50.00% and 93.55%. Conclusion ：The sensibility of serum level CA 199 in patients with non-serous epithelial ovarian carcinoma was much higher than that in patients with serous epithelial ovarian carcinoma. The preoperative serum levels of CA199 were related to the histological type, FIGO stage and differentiation（P 〈 0.05 ）,which can help us in the early detection of recurrence.
出处
《天津医药》
CAS
北大核心
2009年第3期186-188,共3页
Tianjin Medical Journal
