摘要
在溶液条件下,左旋3,4-二羟基苯丙氨酸(L-DOPA,或L-多巴)能在固体材料表面自发聚合,形成强力附着于材料表面的poly(DOPA)层.基于L-DOPA的这一特性,对聚乙烯(PE)微孔膜进行了表面改性,得到了PE/poly(DOPA)复合膜,并进一步通过poly(DOPA)层上的反应性基团将肝素共价固载在PE微孔膜上.X光电子能谱(XPS)分析结果证实了poly(DOPA)和肝素的固定,接触角测量数据表明膜的亲水性得到了显著提高.
A new and convenient approach for surface immobilization of heparin onto PE porous membranes is reported.3,4-dihydroxy-L-phenylalanine （L-DOPA）, a catecholic amino acid, is an important component of mussel adhesive proteins （MAPs）. Based on the strong adhesive behavior of poly（DOPA） on solid surface, hydrophobie PE porous membranes was surface-modified by self-polymerization of L-DOPA in aqueous solution. Subsequently, heparin was immobilized covalently onto PE/poly （DOPA） composite membranes by the coupling between heparin and poly （DOPA） layer. The immobilization of poly （DOPA） and heparin was confirmed by X-ray photoelectron spectroscopy （XPS）. The results of water contact angle measurements showed that the hydrophilieity of PE membranes was significantly improved by the introduction of poly（DOPA） and heparin. The effects of poly（DOPA） and heparin on membrane surface morphologies were also investigated by scanning electron microscopy （SEM）. Despite the decreased pore amount and pore size on membrane surface after poly（DOPA） and heparin immobilization, the improved hydrophilicity would be beneficial to promote permeability and biocompability of PE membranes.
出处
《高分子学报》
SCIE
CAS
CSCD
北大核心
2009年第4期394-397,共4页
Acta Polymerica Sinica
基金
国家自然科学基金(基金号50803054)
国家重点基础研究发展计划(973计划
项目号2007C13623402)资助项目
关键词
多巴
聚乙烯微孔膜
自聚合
肝素固定
DOPA （3,4-dihydroxy-L-phenylalanine）, Polyethylene mieroporous membranes, Self-polymerization,Heparin immobilization
