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瑞芬太尼产生超敏现象的机制与防治 被引量：7

Mechanism and treatment of remifentanil induced hyperanalgesia
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摘要 瑞芬太尼是目前临床使用的作用时间最短的μ阿片镇痛药，但临床应用中不少临床麻醉医师发现瑞芬太尼停药后可能出现痛觉超敏的现象。超敏有多种机制参与，涉及体内阿片类物质的平衡，NMDA通路的调控，α肾上腺受体的调控等。对超敏的防治方法，主要有中长效阿片药物，及选用氯胺酮、陆马多、奈福泮、加巴喷汀等非阿片类药物治疗。 Remifentanil, the shortest on-time and off-time μ opioid receptor analgesic, is found to produce hyperanalgesia after termination of administration. Many mechanisms, such as opioid balance, NMDA pathway control, a-receptor modification are involved in hyperanalgesia. Middle-and long-acting opioids, ketamine, tramadol, nefopam, gabapentin are useful to treat hy-peranalgesia.
作者 周仁龙 杭燕南
机构地区 上海交通大学医学院附属仁济医院麻醉科
出处 《国际麻醉学与复苏杂志》 CAS 2009年第2期177-180,共4页 International Journal of Anesthesiology and Resuscitation
关键词 瑞芬太尼 超敏 机制 防治方法 Remifentanil Hyperanalgesia
分类号 R96 [医药卫生—药理学]
  • 相关文献

参考文献30

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二级参考文献10

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共引文献17

同被引文献48

  • 1郁葱,罗玉林,肖水生,李勇,张青.比较曲马多与小剂量氯胺酮对瑞芬太尼麻醉术后的镇痛作用[J].华西口腔医学杂志,2005,23(5):404-406. 被引量：18
  • 2张卫,王中玉,庆淑梅,李莉.不同速率输注瑞芬太尼对老年患者气管插管反应的影响[J].中华麻醉学杂志,2006,26(2):114-117. 被引量：41
  • 3李治松,张卫.瑞芬太尼临床作用的研究进展[J].国际麻醉学与复苏杂志,2007,28(1):56-58. 被引量：16
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  • 8Kapfer B, Alfonsi P, Guignard B, et al. Nefopam and ketamine comparably enhance postoperative analgesia[J]. Anesth Analg, 2005, 100(1): 169 - 174.
  • 9Wright DR,Thornton C,Hasan K,et al. The effect of remifentanil on the middle latency auditory evoked response and haemodynamike measurements with and without the stimulus of orotracheal intubation. Eur JAnaesthesiol,2004,21:509-516.
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引证文献7

二级引证文献54

国际麻醉学与复苏杂志
2009年 第2期

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