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Balb/c 3T3细胞体外转化实验及其在环境致癌物检测上的应用 被引量：4

Balb/c 3T3 cell transformation assay and its application to the screening of carcinogens
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摘要 Balb/c 3T3细胞体外转化实验是利用Balb/c 3T3细胞在体外培养的环境下,模拟致癌物在动物体内致瘤过程进行致癌物筛选的一种技术,它的检测终点是正常细胞转化为恶性细胞时获得的恶性表型。本文就其方法的发展和改进,以及其在肿瘤启动剂和促癌剂检测上的应用进行了综述。 A cell transformation assay may be an in vitro assay measuring the phenotypic conversion from normal to malignant characteristics in Balb/c 333 cells exposed to test chemicals, and capable of detecting carcinogens. In this article, the progress and improvement of Balb/c 333 cells transformation assay, and its applications in the detection of tumor initiator and promoter were reviewed.
作者 张磊 曾毅
机构地区 中国疾病预防控制中心病毒病预防控制所
出处 《卫生研究》 CAS CSCD 北大核心 2009年第2期226-232,共7页 Journal of Hygiene Research
基金 国家科技支撑计划项目(No.2006BAI19B03)
关键词 BALB/C 3T3细胞 细胞转化 致癌物 环境毒理 Balb/c 3T3 cells, cell transformation, carcinogens, environmental toxicology.
分类号 R994.6 [医药卫生—毒理学] Q26 [生物学—细胞生物学]
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参考文献51

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共引文献30

同被引文献64

  • 1王李伟,仲伟鉴,应贤平,周永贵,周祥凤.三羟异黄酮对BALB/c-3T3细胞的转化作用[J].癌变．畸变．突变,2005,17(1):48-51. 被引量：7
  • 2张京京,王斌,贾文丽,王怀生.碳纳米管修饰电极研究鸟嘌呤及其核苷的电化学行为及测定[J].化学传感器,2007,27(2):57-63. 被引量：4
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引证文献4

二级引证文献3

卫生研究
2009年 第2期

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