摘要
用１５３Ｓｍ－ＥＤＴＭＰ（ｅｔｈｙｌｅｎｅｄｉａｍｉｎｅｔｅｔｒａｍｅｔｈｙｌｅｎｅＰｈｏｓｐｈｏｎｉｃａｃｉｄ）治疗多发性骨转移癌６０例，其原发灶均经病理及细胞学证实。静脉一次给予量为１４．８～２９．６ＭＢｑ／ｋｇ体重，多数病人（５０／６０）按１８．５ＭＢｑ／ｋｇ体重计算治疗剂量，一般病人治疗１～４次，两次治疗间隔为４～８周。止痛有效率为８１．７％（４９／６０），给药前２周内９９ｍＴｃ－ＭＤＰ与给药后１５３Ｓｍ－ＥＤＴＭＰ全身骨显像进行观察比较。随访１～１２个月，认为１５３Ｓｍ－ＥＤＴＭＰ治疗多发性骨转移癌疗效好、副反应小。
Sixty patients with disseminated bone metastases were treated with 153SmEDTMP (ethylenediaminetetramethylene phosphoric acid). A single intravenous dose of 14.829.6 MBq/kg body weight was given. Generally the patient received 1 to 4 injections with an interval of 48 weeks. The analgesic rate was 81.7% (49/60).Comparison was made with 99mTcMDP given two weeks previously as shown by 153SmEDTMP single photon emission computed tomography after treatment,it was noted that 153SmEDTMP is more effective, less sideeffect and safer in the treatment of disseminated skeletal metastatic cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1998年第7期524-526,共3页
Chinese Journal of Clinical Oncology
