摘要
在全国３２家医院，采用多中心对照方法，进一步观察重组牛碱性成纤维细胞生长因子（ｂＦＧＦ）对创面修复的影响和可能发生的毒副反应。结果表明，在统一病例选择范围、治疗方法及治疗标准的前提下，３２家医院经ｂＦＧＦ治疗的１０２４例烧伤（３３０例）、手术创伤或供皮区创面（５０９例）及慢性难愈合创面（１８５例）均较对照创面（８２６例，其中１８５例为自身对照）修复质量显著提高，创面愈合时间分别缩短３天～４天。ｂＦＧＦ对烧伤、手术创伤、供皮区创面及慢性难愈合创面促修复的有效率分别为９５．２％、９６．５％和９３．５％。
To evaluate the effects of bFGF on wound healing and the sideeffects of bFGF, a multicenters and controlled clinical trial were carried out in 32 hospitals in China. One thousand and twentyfour cases with acute wounds such as burn, donor site or operative wound and chronic wounds such as bed sore, draining sinus, ulcer were treated with bFGF. Another 826 cases with the similar wounds were used as control. The results showed: ①The duration of wound healing was shorted 3～4 days in trial group when compared with the control; ②The successful rates from bFGF on promoting the wound healing for burns, operative wounds and chronic dermal ulcers was 95.2%, 96.5% and 93.5%, respectively; ③No adverse reaction was found. Conclusion: ①bFGF can make the “silent” reparative cells dividing and proliferating. ②bFGF can improve the quality and the velocity of wound healing.
出处
《中国修复重建外科杂志》
CAS
CSCD
1998年第4期209-211,共3页
Chinese Journal of Reparative and Reconstructive Surgery
