摘要
目的探讨低分子肝素（LMWH）治疗重症急性胰腺炎的机理。方法建立假手术组（S组）、重症急性胰腺炎组（SAP组）和LMWH治疗组（H组），比较各组死亡率、血清淀粉酶、IL-6、腺泡细胞凋亡指数和胰腺组织NF-κB活性。结果H组死亡率、血清淀粉酶和IL-6明显低于SAP组（P〈0．01）。H组腺泡细胞凋亡指数明显高于SAP组（P〈0．01）。H组胰腺组织NF-κB活性明显低于SAP组。结论LMWH可能通过抑制NF-κB的活性，从而诱导了胰腺腺泡细胞凋亡，减轻胰腺炎症程度。
Objective To explore the mechanism of LMWH therapy for SAP. Methods 48 wistar rats were random divided into 3 groups, sham group （S group） , severe acute pancreatitis group （SAP group） and LMWH therapy group （H group）. Serum amylase, IL-6, aeinar cell apoptosis and the activity of NF-κB were detected and compared： Results The expression of amylase and IL-6 in SAP group was significantly higher than that in H group （ P 〈0. 01 ）. The apoptosis index of aeinar cell in SAP group was significantly lower than that in H group （ P 〈 0. 01 ）, while the activity of NF-κB in SAP group was stronger than that in H group. Conclusions LMWH therapy may amelio- rate SAP by inducing aeinar cell apoptosis through suppressing the activity of NF-κB.
出处
《中国医师杂志》
CAS
2009年第3期342-344,共3页
Journal of Chinese Physician
