摘要
近年来发现青蒿紊及其衍生物具有抗肿瘤作用，其机制与细胞毒作用、氧化应激直接杀伤肿瘤细胞、诱导细胞凋亡、抑制增殖；抑制血管生成和免疫调节等作用有关。与传统的抗肿瘤药物相比，青蒿素类药物可选择性杀伤肿瘤细胞，且不存在交叉耐药、逆转肿瘤细胞的多重耐药现象。本文将青蒿素及其衍生物的抗肿瘤作用研究现状做一归纳。
Artemisinin is a traditional anti-malarial drug. In recent years, many researches indicated that artemisinin and its derivatives have obvious anti-tumor effects. Its mechanisms of anti-tumor lies in cytotoxicity, direct destruction of tumor cells due to oxidative stress reaction, inducing apoptosis, inhibiting of tumor cell proliferation, restraining tumor angiogenesis and performing immunological regulation. Compared with the traditional anti-cancer drugs, artemisinin can selectively inhibit tumor cells and manifestating no cross-resistance with traditional chemotherapeutic agents. Besides it can reverse the phenomenon of multi-drug resistant of tumor cells. Therefore, artemisinin, as an new type of anti-cancer drug, will be applied to a wide range of clinical practice.
出处
《国际中医中药杂志》
2009年第2期174-175,184,共3页
International Journal of Traditional Chinese Medicine
