摘要
目的探讨急性病毒性心肌炎患儿血清肿瘤坏死因子-α(TNF-α)及白介素-6(IL-6)水平变化及其临床价值。方法应用放射免疫法(RIA)和酶联免疫法(EIISA),检测53例急性病毒性心肌炎患儿及20名健康儿童血清中TNF—α及IL-6含量。结果心肌炎组血清TNF—α和IL-6水平分别为(526.7±32.9)mg/L和(3.23±0.53)mg/L,而健康组分别为(383.1±27.5)mg/L和(1.63±0.22)mg/L,二者相比差异有统计学意义(P〈0.05);临床治愈后,心肌炎组TNF—α及IL-6分别降至(407.3±34.4)mg/L和(1.97±0.29)mg/L,与正常组相比差异无统计学意义(P〉0.05)。结论检测TNF—α及IL-6血清水平及其变化,有助于判断急性病毒性心肌炎患儿病情及心肌损害程度。
Objective To assess the clinical value of changes of tumor necrosis factor-α and interleukin- 6 level in the children with acute viral myocarditis (AVM). Methods TNF-α and IL-6 levels in serum from 53 viral myocarditis children and 20 healthy children were measured by radio-immunoassay(RIA) and enzyme-linked immunosorbent assy (EIISA), and then analysed the correlation between the levels of TNF-α and IL-6 in serum and the occurance and development in acute viral myocarditis. Results The serum levels of TNF-α and IL-6 of the AVM group were much higher than those of the control group(P〈0.05), there was no obvious difference of the serum level of TNF-α and IL-6 between the patients after AVM clinical recovery and the normals. Conclusion Determination of TNF-α and IL-6 levels is useful to judge the severity of AVM and its heart damage.
出处
《中国心血管病研究》
CAS
2009年第4期285-287,共3页
Chinese Journal of Cardiovascular Research