摘要
研究了斑蝥黄质对高脂饲料喂养下大鼠诱发高血脂症过程中干预血脂代谢的情况.将60只SD雄性大鼠随机分为正常对照组、高血脂模型组、辛伐他汀阳性药组(15 mg/kg)、斑蝥黄质高剂量组(20 mg/kg)、斑蝥黄质中剂量组(15 mg/kg)、斑蝥黄质低剂量组(10 mg/kg),分别饲喂标准、高脂、高脂+辛伐他汀、高脂+不同剂量斑蝥黄质,于实验开始前1天和开始后第4,8,12周末取空腹血,检测血清甘油三酯(TG)、总胆固醇(TC)和高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C).与高血脂模型组比较,斑蝥黄质组的TC,TG,LDL-C在第8,12周时降低(P<0.01),而HDL-C升高(P<0.01).研究表明斑蝥黄质可以对高脂饲料喂养大鼠诱发高血脂症过程中血脂代谢产生影响,改善血脂变化.
To observe the effect of canthaxanthin on the lipid level of SD rat by high fat feed,60 SD male rats were randomized into six groups with 10 rats in each group.They were individually housed in metal cages in an air-conditioned room.Throughout the experimental period,they were given restricted amounts of food（40～50 g/d）per diet,with no limit of drinking.The control group was fed with standard diet.The hyperlipidemia model group was fed with standard diet containing cholesterol.The canthaxanthin group was fed with standard diet containing cholesterol plus simvastatin.All the rats were fed for twelve weeks.Blood samples were drawn just before the experiment and at the fourth,the eighth,the twelveth weekend of the experiment.The blood samples were analyzed for total cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C）and low density lipoprotein cholesterol（LDL-C）and measured enzymatically by automatic facilities.Compared with the hyperlipidemia model group,the TC,TG and LDL-C level was lower markedly by dietary canthaxanthin at the twelveth weekend（P〈0.01）,but HDL-C level was higher than the hyperlipidemia model.Canthaxanthin may effect the lipid level of rat by high fat feed.
出处
《河北师范大学学报（自然科学版）》
CAS
北大核心
2009年第2期236-239,共4页
Journal of Hebei Normal University：Natural Science
基金
北京市自然科学基金对外合作项目(SZ20051141720)
关键词
斑蝥黄质
血脂
高血脂症大鼠
canthaxanthin
lipid level
hyperlipidemia rat
