摘要
目的了解血吸虫病脾脏厚度与肝纤维化程度的相关性,探讨应用无创性的检查方法来评估血吸虫病肝纤维化的程度。方法收集169例血吸虫病患者脾脏切除和术中肝活检组织标本,测量脾脏厚度(SPT),应用苦味酸天狼猩红特殊染色,对肝组织进行纤维化分期诊断。结果血吸虫病肝纤维化S1～S4期对应的脾脏厚度分别为(54.7±4.9)、(56.6±6.4)、(63.8±10.5)、(70.4±16.3)mm,S1～S4期脾脏逐渐增厚;肝纤维化S3或S4期与S1或S2期之间的脾脏厚度有显著性差异(P<0.05)。结论脾脏厚度对诊断血吸虫病患者肝纤维化程度有一定的参考价值。
Objective To understand the relationship between the thickness of spleen and the scale of liver fibrosis, and to explore the possibility of application of non invasive examination to assess the scale of liver fibrosis in schistosomiasis patients. Methods Medical records, spleen specimensand tissues of liver biopsy of 169 cases with schistosomiasis were collected. The thickness of spleens （SPT） was measured. Picrosiriusred staining was applied to diagnose the scales of liver fibrosis. Results The thickness of spleen in schistosomiasis cases with SI - S4 period liver fibrosis was 54. 7 ± 4.9mm, 56.6 ± 6.4mm, 63.8 ± 10.5mm, and 70.4 ± 16.3mm, respectively. The thickness of spleen gradually thickened with the scaling （from S1 to S4） of liver fibrosis. There was significant difference in the thickness of spleen between cases with liver fibrosis S3--S4 and ones with liver fibrosis S1 --S2 （P〈 0.05）. Conclusions Measuring the thickness of spleen has diagnosis capacity for the scaling of liver fibrosis in schistosomiasis patients
出处
《实用预防医学》
CAS
2009年第2期350-351,共2页
Practical Preventive Medicine
基金
湖南省卫生厅重点课题基金(课题编号:A2004-2006)
关键词
血吸虫病
肝纤维化
脾脏厚度
手术
苦味酸天狼猩红
Schistosomiasis
Liver fibrosis
Thickness of spleen
Operation
Picrosiriusred
