摘要
目的研究p27KIP1和Ki-67抗原在乳腺癌中的表达及其关系。方法应用免疫组化SP法对56例乳腺癌中p27KIP1和Ki-67的表达情况进行观察。结果p27KIP1的高表达率为41.1%(23/56),低表达率为58.9%(33/56),Ki-67的高表达率为66.1%(37/56),低表达率为33.9%(19/56),p27KIP1蛋白与Ki-67的表达间存在着负性相关(P<0.05)。结论p27KIP1、Ki-67的异常表达在乳腺癌发生发展过程中起重要作用,癌细胞增殖活性的改变直接与肿瘤的恶性程度有关。
Objective To explore the expression of p27^KIP1and Ki - 67 and their significance in breast cancer. Methods Immunohistochemical SP was used to investigate the expression of p27^KIP1 and Ki - 67 in 56 cases with breast cancer. Results The high expression rate of p27^KIP1 was 41.1% （23/56）, while the low expression rate of p27^KIP1 was 58.9% （33/56）. The high expression rate of Ki - 67 was 66.1% （37/56）, while the low expression rate of Ki - 67 was 33.9 % （ 19/ 56）. Significant negative correlation was observed between p27^KIP1 protein and Ki- 67 expression （P〈 0.05）. Conclusions Aberrant expression of p27^KIP1 and Ki-67 play a very important role in pathogenesis and development of breast cancer, and the changes of proliferative activity of cancer cells are directly related to the degree of malignant tumors.
出处
《实用预防医学》
CAS
2009年第2期478-479,共2页
Practical Preventive Medicine
