摘要
目的探讨急性一氧化碳(CO)中毒患者血清S-100β蛋白水平与病情严重程度和对预后的关系,以及其对患者充足疗程的治疗指导临床意义。方法将81例急性CO中毒患者分为三组:A组轻度组、B组中度组和C组重度组,应用ELISA法对81例急性CO中毒患者的血浆S-100β蛋白水平进行检测。结果重度组与中度组血浆S-100β蛋白水平均明显高于轻度中毒组(P<0.01),且重度组血浆S-100β蛋白水平明显高于中度组(P<0.05);迟发性脑病患者均发生在重度组,其血浆中S-100β蛋白水平与其它组的比较差异有显著性(P<0.05);重度组中的CO中毒死亡只有3例,未对其做统计。结论检测急性CO中毒患者的血清S-100β蛋白水平,有助于评估急性期脑组织受损的严重程度及预测迟发性脑病的发生。
Objective： To observe plasm S-100β protein levels in patients and explore its relationship with the severe degree of acute carbonmonoxide poisoning and the prognostic value of S100β protein, and the clinical significance of the adequate treatment in patients. Methods：81 patients with acute carbon monoxide poisoning were divided into three groups：groupA（Gentleness poisoning group） ,groupB （moderate poisoning group ）and groupC（ severe poisoning group） .Plasma S-100 proptein levels of 81patients were detected respectively with Enzyme-linked immunosobent assay ELISA. Results： The levels of plasm S-100β protein in group B and groupC were significantly higher than that in the control group A（P〈0.05）, PlasmS-100β protein level in group C was obviously higher than in group B also （P〈0.05）.There was statistically significant difference in the plasma S-100β protein level between the patients with deLayed encephalopathy which all occurred in groupC and those in other groups（ P〈0.05 ）. There was no statistical conclusion of the plasma S-100β protein level in the 3 patients .Conclusion： Determination of plasm S-100protein Level can contribute to assessing the severe degree of acute carbonmonoxide？ poisoning,and it can also predict the occurrence of delayed encephalopathy.
出处
《当代医学》
2009年第7期89-90,共2页
Contemporary Medicine
