摘要
杯[4]芳烃经醚化、氨解得到了含酰肼基团的中间体3,在PEG-400存在下,肉桂酰氯与3反应获得了含肉桂酰基的杯[4]芳烃衍生物4;4-羟基肉桂酸与氯甲酸乙酯形成的混合酐与3反应,得到了相应的化合物5。用1 HNMR,13C NMR及IR对4,5进行了结构表征,用MS对4进行了结构确证。DPPH.法测定4,5清除有机自由基活性的结果表明,4,5的自由基清除率约为19%,比杯[4]芳烃母体及肉桂酸都有所提高。
Cinnamyl calix[4] arene derivative was synthesized by reaction of cinnamonyl chloride with intermediate 3 containing hydrazide radical group generated by etherification and ammonolysis of calix[4] arene with present of PEG-400. Compond 5 was produced by reaction of ammonolysis 3 with mixed anhydride generated by reaction of 4-hydroxy einnamic acid with ethyl chlorocarbonate. The structures of 4, 5 were characterized by ^1H NMR,^13C NMRand IR, and 4 by MSalso. The efficieney of free radical elimination of 4, 5 with DPPH·method was about 19%, higher than calix[4]arene and cinnamic acid.
出处
《安徽理工大学学报（自然科学版）》
CAS
2009年第1期31-33,62,共4页
Journal of Anhui University of Science and Technology:Natural Science
关键词
芳烃衍生物
合成
自由基清除活性
cinnamyl callix[4]arene derivatives
synthesis
free radical activity elimination
