摘要
目的：研究齐酞酸钠对大鼠实验性肝损伤的保护作用，并与齐墩果酸进行量效比较。方法：采用化学毒物Ｄ氨基半乳糖和四氯化碳致大鼠肝脏损伤，测定生化指标及观察病理组织学改变。结果：齐酞酸钠呈剂量依赖性地明显降低Ｄ氨基半乳糖、四氯化碳引起的大鼠血清丙氨酸转移酶（ＡＬＴ）增高；显著减轻肝脏中脂肪蓄积；病理组织学检查齐酞酸钠明显减轻肝细胞的变性和坏死。结论：齐酞酸钠对大鼠实验性肝损伤有明显的保护作用，在同等剂量下上述作用优于齐墩果酸。
OBJECTIVE: To investigate the protective effects of OLAPENa on experimental hepatic injury in rats and compare it with OLA in the doseresponse relationships. METHODS: Biochemical indexes and histopathological examination of hepatic injury in rats caused by toxicant chemicals Dgalactosamine (DGaln) and CCl4] were determined. RESULTS: OLAPENa obviously inhibited the rising of serum alanine transaminase (ALT) caused by DGaln and CCl4 and dramatically decreased liver fat storage as well in a dosedependent manner. Histopathological examination showed that OLAPENa can evidently alleviate the condition of the degeneration of hepatic cells and that of necrosis. CONCLUSION: The protective effects of OLAPENa on experimental liver injury in rats, all the mentioned effects, are more powerful than those of OLA with the same dosage.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1998年第2期80-83,共4页
Chinese Pharmaceutical Journal
基金
贵州省科学技术基金
关键词
齐酞酸钠
肝损伤
药理学
齐墩果酸
OLAPENa (oleanolic acid 3βphthalic monoester disodium salt), experimental hepatic injury
