摘要
目的探讨冠心病患者血浆心钠素（ＡＮＦ）与左房血流动力学变化的关系。方法应用超声心动图技术和放射性免疫测定法，对１０６例冠心病患者左房血流动力学变化与ＡＮＦ水平进行相关性分析。结果心绞痛组、心肌梗塞组及缺血性心肌病组的ＡＮＦ水平显著高于正常对照组；并与左房功能指标ＬＡＶ、ＬＡＴ、ＬＡＰ、ＬＡＤ、ＬＡＳＶ和ＬＡＥＦ呈高中度线性相关意义；与左室收缩及舒张功能指标：ＬＶＥＦ、ＬＶＤ、ＰＦＲ、Ａ峰、Ａ／Ｅ呈中度线性相关意义（Ｐ＜０．０１～０．００１）。结论测定ＡＮＦ水平对于评价左房室功能异常变化有重要意义。
Objective To investigate the relationship between plasma atrial natriuretic factor(ANF) levels and changes of left atrial hemodynamics in patients with coronary heart disease (CHD). Methods Plasma ANF level and left atrial function as well as the changes of hemodynamics in 106 patients with CHD and 50 normal control (NC) group were measured by two dimensional Doppler echocardiography and radioimmunoassay.Results The plasma level of ANF concentrations in 36 angina pectoris(AP) group, 40 myocardial infarction(MI) group and 30 ischemic cardiomyopathy (ICM) group was higher than NC group (P<0.01 or 0.001).Significant linear correlation existed between plasma level of ANF and the indexes of left atrial function:left atrial volume(LAV), left atrial tension(LAT),left atrial pressure(LAP),left atrial diameters( LAD),left atrial stroke volume(LASV) and left atrial ejection fraction(LAEF);the correlation coefficients were 0.79,0.74,0.69,0.682,0.66, 0.64 (P<0.01 or 0.001).Moderate linear correlations existed between plasma level of ANF and left ventricular systolic or diastolic function indexes: left ventricular ejection fraction (LVEF),left ventricular diameters ( LVD) ,peak filling rate (PFR),peak velocity A and A/E ratio: the correlation coefficients were -0.60,0.58,-0.58,0.52,0.44 (P<0.01 or 0.001). Conclusion Detection of ANF level is usful in estimation of left atrial ventricular hemodynamic changes in patients with CHD.
出处
《中华物理医学杂志》
CAS
CSCD
1998年第1期38-41,共4页
Chinese Journal of Physical Medicine and Rehabilitation
关键词
冠心病
人素
左房功能
超声心动图
coronary disease/blood
coronary disease/diag
sodium/metab
echocardiography
