摘要
方法：采用液体缺锌饲料灌胃的方式使大鼠缺锌二周。采用Ｙ－迷宫实验和原子吸收及放射免疫分析技术，分别测定大鼠的学习记忆行为，血清锌含量和海马生长抑素（ＳＳ）、精氨酸加压素（ＡＶＰ）水平的变化。结果：与正常对照组相比，缺锌大鼠在Ｙ－迷宫中达到学会标准所用的时间明显增多（Ｐ＜０．０５）；血清锌含量明显降低（Ｐ＜０．０５）；海马ＳＳ和ＡＶＰ水平明显降低（Ｐ＜０．０１）。结论：在缺锌状态下，海马内的ＳＳ和ＡＶＰ水平是降低的，这种变化可能是缺锌影响脑的智力发育的重要因素之一。
he zinc deficiency rat models were established with zinc deficient fluid feeding(30ml/day).On the 15th day,the changes of learning and memory behavior,serum zinc content and hippocampal somatostatin(SS)and arginine vasopression(AVP)levels of the zinc deficiency rat were measured with Ymaze test,atomic absorption and radioimmunoassay technique.The results were as follows:The zinc deficiency rats took much time to acquire the task in Ymaze test;Its serum zinc content and hippocampal SS and AVP levels were markedly decreased.The results indicated that the hippocampal SS and AVP levels were obviously decreased under zinc deficient status,which in turn might be one of the factors which influenced the intelligence development.
出处
《营养学报》
CAS
CSCD
北大核心
1998年第1期21-24,共4页
Acta Nutrimenta Sinica
基金
全军医药科研基金
关键词
海马
生长抑素
精氨酸加压素
锌缺乏
hippocampus somatostatin argininevasopressin zincdeficiency
