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SOCS3与瘦素抵抗

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出处 《中国妇幼保健》 CAS 北大核心 2009年第11期1589-1590,共2页 Maternal and Child Health Care of China
基金 国家自然科学基金资助项目(项目编号:30771798)
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参考文献9

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  • 2Bjorbaek C, Elmquist JK, Frantz JD et al. Identification of SOCS -3 as a potential mediator of central leptin resistance [J].Mol Cell, 1998, 1 (4): 619
  • 3Dunn SL, Bjomholm M, Bates SH et al. Feedback inhibition of leptin receptor/Jak2 signaling via Tyrl 138 of the leptin receptor and suppressor of cytokine signaling 3 [J]. Mol Endocrinol, 2005, 19 (4) : 925
  • 4Howard JK, Cave B J, Oksanen LJ et al. Enhanced leptin sensitivity and attenuation of diet - induced obesity in mice with haploinsufficiency of Socs3 [J].Nat Med, 2004, 10 (7) : 734
  • 5Mori H, Hanada R, Hanada T et al. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet- induced obesity [J]. Nat Med, 2004, 10 (7) : 739
  • 6Steinberg GR, McAinch AJ, Chert MB et al. The suppressor of cytokine signaling 3 inhibits leptin activation of AMP - kinase in cultured skeletal muscle of obese humans [J]. J Clin Endocrinol Metab, 2006, 91 (9) : 3592
  • 7Story D J, Stenphens JM. Modulation and lack of cross - talk between signahransducer and activator of transcription 5 and suppressor of cytokine signaling - 3 in insulin and growth hormone signaling in 3T3 - L1 adipocytes [J] . Obesity, 2006, 14 (8) : 1303
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  • 9Rui L, Yuan M, Frantz D et al. SOCS- 1 and SOCS-3 block insulin signaling by ubiquitin - mediated degradation of IRS1 and IRS2 [J]. J Biol Chem, 2002, 277 (44): 42394

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