摘要
目的建立适用于动眼神经脑池段压迫性损害病理变化研究的动物模型。方法 10只新西兰白兔显微手术暴露兔动眼神经脑池段及其邻近的后交通动脉,在两者之间放入6F硅胶管压迫动眼神经,压迫损害造成动眼神经麻痹。结果实验手术均被所有实验兔耐受,胶管直接压迫动眼神经脑池段迅速引起兔动眼神经损害,表现出不同程度的动眼神经麻痹。结论应用于动眼神经脑池段压迫性损害病理变化研究的动物模型已经建立,此模型具有良好的可行性和可重复性,有益于动脉瘤动眼神经麻痹的病理研究。
Objective Objective To establish a feasible and reproducible rabbit model of oculomotor nerves injury,and to observe the pathological changes of the oculomotor palsy caused by cisternal segment of oculomotor nerve compression.Methods The cisternal segment of oculomotor nerves were exposed in 10 New Zealand white rabbits after microsurgery,oppression by silicone tube,the oculomotor nerve was made palsy.Results All the procedures used in the study were tolerated well by New Zealand white rabbits.Varying degree of oculomotor nerve palsy was made by silicone tube oppression immediately.Conclusion The animal models have been established to study the pathological changes of the oculomotor injury and have shown great feasibility and reproducibility.It will benefit the investigation of oculomotor nerves caused by artery aneurysm.
出处
《吉林医药学院学报》
2012年第5期267-269,共3页
Journal of Jilin Medical University
基金
吉林省教育厅"十一五"科学技术研究项目(2008268)
关键词
动眼神经
动脉瘤
病理学
兔
oculomotor nerve
artery aneurysm
pathology
rabbit
