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TGF-β1与肝纤维化及肝癌的关系

The relationship of TGF-β1 with hepatic fibrosis and hepatoma
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摘要 转化生长因子β1(TGF-β1)是肝脏病理损伤过程中重要的因子之一,是导致肝纤维化或肝硬变乃至肝癌的重要原因。本文就目前TGF-β1在肝损伤过程中的分子生物学作用进行了综述。
作者 李瑶 张宸豪 李妍
机构地区 吉林医药学院病原教研室
出处 《吉林医药学院学报》 2012年第5期312-314,共3页 Journal of Jilin Medical University
关键词 转化生长因子Β1 肝纤维化 肝癌
分类号 R575.2 [医药卫生—消化系统]
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参考文献5

  • 1Gong J,Ammanamanchi S,Ko TC,et al.Transforming growth factor beta 1 increases the stability of p21/WAF1/CIP1 protein and inhibits CDK2 kinase activity in human colon carcinoma FET cells. Cancer Research . 2003
  • 2Do TV,Kubba LA,Du H , et al.Transforming Growth Factor-{beta} 1, Transforming Growth Factor-{beta} 2, and Transforming Growth Factor-{beta} 3 Enhance Ovarian Cancer Metastatic Potential by Inducing a Smad3-Dependent Epithelial-to-Mesenchymal Transition. Molecular Cancer Research . 2008
  • 3Ozaki I,Hamajima H,Matsuhashi S,et al.Regulation of TGF-β1-induced Pro-Apoptotic Signaling by Growth Factor Receptors and Extracellular Matrix Receptor Integrins in the Liver. Front Physiol . 2011
  • 4Kawelke N,Vasel M,Sens C,et al.Fibronectin protectsfrom excessive liver fibrosis by modulating the availabilityof and responsiveness of stellate cells to active TGF-β. PLoS One . 2011
  • 5Franck Verrecchia,Alain Mauviel.Transforming growth factor-β and fibrosis[J].World Journal of Gastroenterology,2007,13(22):3056-3062. 被引量：114

二级参考文献74

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共引文献113

吉林医药学院学报
2012年 第5期

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