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视神经脊髓炎治疗进展 被引量：8

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摘要 视神经脊髓炎是一种发生在中枢神经系统的炎性自身免疫性疾病,病变多局限于视神经和脊髓,早期很少累及脑[1]。现有的资料提示,视神经脊髓炎发生的机制是致敏B淋巴细胞产生的特异性抗体结合补体,沉积并破坏血脑屏障的水通道蛋白-4以及巨噬细胞、嗜酸粒细胞等趋化渗出,分泌炎性因子,继而导致髓鞘脱失、轴索和组织坏死。某种程度上类似血管炎变化,
作者 耿同超 黄方杰
机构地区 清华大学玉泉医院神经科
出处 《中华临床医师杂志（电子版）》 CAS 2012年第23期7506-7509,共4页 Chinese Journal of Clinicians(Electronic Edition)
关键词 视神经脊髓炎 髓鞘脱失 嗜酸粒细胞 水通道蛋白 自身免疫性疾病 多发性硬化 血脑屏障 中枢神经系统 血管炎 轴索
分类号 R744.52 [医药卫生—神经病学与精神病学]
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参考文献25

  • 1Yan Xu,Yao Zhang,Jing Ye,Bin Peng,Jian-Ming Wang,Li-Ying Cui.Successful treatment of a woman with relapsing neuromyelitis optica by interferon beta[J]. Neurological Sciences . 2012 (4)
  • 2Dr. Y. Shimizu,K. Yokoyama,T. Misu,T. Takahashi,K. Fujihara,S. Kikuchi,Y. Itoyama,M. Iwata.Development of extensive brain lesions following interferon beta therapy in relapsing neuromyelitis optica and longitudinally extensive myelitis[J]. Journal of Neurology . 2008 (2)
  • 3Mandler RN,Ahmed W,Dencoff JE.Devic’s neuromyelitis optica: a prospective study of seven patients treated with prednisone and azathioprine. Neurology . 1998
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同被引文献75

  • 1de Seze J,Collongues N.Novel advances in the diagnosis and treatment of neuromyelitis optica:is there a need to redefine the gold standard?[J].Expert Rev Clin Immunol,2013,9(10):979-986.
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  • 3Marcus JF,Waubant EL.Updates on clinically isolated syndrome and diagnostic criteria for multiple sclerosis[J].Neurohospitalist,2013,3(2):65-80.
  • 4吴珍,张献玲,朱芬燕.大剂量激素冲击治疗视神经脊髓炎fNMO)的护理[J].医药前沿,2014,18:286-287.
  • 5WINGERCHUK DM,BANWELL B,BENNETT JL,et al.In- ternational consensus diagnostic criteria or neuromyelitis ptica pectrum disorders[J].Neurology,2015,85(2):177-189.
  • 6PAPADOPOULOS MC,VERKMAN AS.Aquaporin 4 and neu- romyelitis optica[J].Lancet Neurol,2012,11(6):535-544.
  • 7WEINSHENKER BG,WINGERCHUK DM.The two faces of neuromyelitis optica[J].Neurology,2014,82(6):466-467.
  • 8JONES MV,FOX TALBOT K,LEVY M.Evidence for classic comp-lement activity in neuromyelitisoptica[J].Clin Neuropathol,2014,33(3):251-252.
  • 9MARIOS C,JEFFREY L,ALAN S.Treatment of neuromyelitis optica:state-of-the-art and emerging therapies[J].Nat Rev Neurol,2014,10(9):493-506.
  • 10YAGUCHI H,SAKUSHIMA K,TAKAHASHI I,et al.Efficacy of intravenous cyclophosphamide therapy for neuromyelitis optica spectrum disorder[J].Intern Med,2013,52(9):969-972.

引证文献8

二级引证文献47

中华临床医师杂志（电子版）
2012年 第23期

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