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不同剂量右美托咪定对术后吗啡镇痛的影响 被引量：4

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摘要 右美托咪定(dexmedetomidine,Dex)是高选择性α2肾上腺素能受体激动剂,具有镇静、镇痛、抗焦虑及交感神经抑制等作用[1-2]。目前对于Dex手术结束前给药减轻术后疼痛国内尚未见文献报道。本文拟对不同剂量Dex的术后镇痛作用和不良反应的发生进行比较。一、资料与方法1.一般资料:选择2010年8月至2011年6月我院48例择期全麻手术患者,ASAⅠ～Ⅱ级,年龄18～60岁,性别不限,体重为标准体重±15%,将患者随机分成4组(C、D1、D2、D3组),每组各12例。C组为对照组给予生理盐水20ml,D1～D3为Dex组(0.5μg/kg、0.8μg/kg、1.0μg/kg,均稀释成20ml),分别于手术结束前30min静脉缓慢输注10min。
作者 斯妍娜 张勇 王宏宇 沈妍 鲍红光
机构地区 南京医科大学附属南京医院(南京市第一医院)麻醉科
出处 《中华临床医师杂志（电子版）》 CAS 2012年第14期4119-4121,共3页 Chinese Journal of Clinicians(Electronic Edition)
基金 南京医科大学科技发展基金项目(2010NJMU052) 南京市医学科技发展项目(201108028)
关键词 吗啡镇痛 全麻手术患者 镇痛作用 术后疼痛 神经抑制 受体激动剂 寒战发生率 抗焦虑 肾上腺素能 作用时间
分类号 R614 [医药卫生—麻醉学]
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参考文献10

  • 1ArcangeliA,D’’GaspariR.Dexmedetormidineuse in general anaesia. Current Drug Targets . 2009
  • 2Schmidt AP,Valinetti EA,Bandeira D,et al.Effects of preanesthetic administration of midazolam,clonidine,or dexmedetomidine on postoperative pain and anxiety in children. Pediatr Anesth . 2007
  • 3Sitilci A T,Ozyuvacl E,Alkan Z,et al.The effect ofperioperative infused dexmedetomidine on postoperativeanalgesic consumption in mastoidectomy operations. Agri . 2010
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  • 8Unlugenc H,Gunduz M,Guler T,et al.The effect of prean-aesthetic administration of intravenous dexmedetomidine onpostoperative pain in patients receiving patient-controlled mor-phine. European Journal of Anaesthesiology . 2005
  • 9Yuen VM,Irwin MG,Hui TW,et al.A double-blind,crossover assess-ment of the sedative and analgesic effects of intranasal dexmedetomi-dine. Anesthesia and Analgesia . 2007
  • 10Gerlach AT,Murphy CV.Dexmedetomidine-associated bradycardia progressing to pulseless electrical activity:case report and review of the literature. Pharmacotherapy . 2009

同被引文献31

  • 1徐辉,史潇,李梅娜,孙来保,曹铭辉.术中静脉应用不同剂量右美托咪定对老年患者术后硬膜外吗啡镇痛的影响[J].中国老年学杂志,2014,34(3):678-680. 被引量：19
  • 2Wahlander S, Frumento R J, Wagener G, et al. A prospective, dou- ble-blind, randomized, placebo-controlled study of dexmedetomi- dine as an adjunct to epidural analgesia after thoracic surgery. J Cardiothorac Vasc Anesth,2005,19:630-635.
  • 3Lin TF, Yeh YC, Lin FS, et al. Effect of combining dexmedetomi- dine and morphine for intravenous patient-controlled analgesia. Br J Anaesth,2009,102:117-122.
  • 4Lin TF,Yeh YC,Lin FS,et al.Effect of combiningdexmedetomidine and morphine for intravenouspatient-controlled analgesia. British Journal of Anaesthesia . 2009
  • 5J-Y. Chen,G-J. Wu,M. S. Mok,Y-H. Chou,W-Z. Sun,P-L. Chen,W-S. Chan,H-W. Yien and Y-R. Wen.Effect of adding ketorolac to intravenous morphine patient-controlled analgesia on bowel function in colorectal surgery patients - a prospective, randomized, double-blind study. Acta Anaesthesiologica Scandinavica . 2005
  • 6Yeh YC,Lin TF,Lin FS,et al.Combination of opioid agonistand agonist-antagonist:patient-controlled analgesia require-ment and adverse events among different-ratio morphine andnalbuphine admixtures for postoperative pain. British Journal of Anaesthesia . 2008
  • 7Michelet P,Guervilly C,Helaine A, et al.Adding ketamine to morphine for patient-controlled analgesia after thoracic surgery: influence on morphine consumption, respiratory function, and nocturnal desaturation. British Journal of Anaesthesia . 2007
  • 8Aouad MT,Al-Alami AA,Nasr VG,et al.The effect of low-dose remifentanil on responses tothe endotracheal tube during emergence from general anesthesia. Anesthesia and Analgesia . 2009
  • 9Unlugenc H,Gunduz M,Guler T,et al.The effect of prean-aesthetic administration of intravenous dexmedetomidine onpostoperative pain in patients receiving patient-controlled mor-phine. European Journal of Anaesthesiology . 2005
  • 10Abdelmalak B,Makary L,Hoban J,et al.Dexmedetomidine as sole sedative for awak e intubation in man agement of the critical airway. Journal of Clinical Anesthesia . 2007

引证文献4

二级引证文献38

中华临床医师杂志（电子版）
2012年 第14期

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