摘要
目的观察不同人群左右侧颈动脉内中膜厚度(CIMT)是否存在差异以及血压、血脂和血糖对它们的影响。方法选择超声图像清晰、颈总动脉无斑块的受检者共612例,年龄(50±15)岁(14～86岁),男399例,女213例;其中,正常人149例,高血压101例,高血脂91例,糖尿病21例,冠心病和脑梗死94例,高血压合并糖尿病或高血脂156例。用高频超声技术探查双侧颈动脉,录像,脱机测量颈总动脉最大厚度(IMTmax)和病变最明显部位39 mm长度节段的平均厚度(IMTave),用配对t检验比较双侧差异性,P<0.05定义为差异有统计学意义。结果总人群、同性别人群、不同风险因子人群的左侧CIMT绝对值都略大于右侧,其中仅有总人群及其男性、30岁以下正常人群、高血压人群及其男性、高血脂人群及其男性左右侧IMTave值的差异存在显著性,女性冠心病和脑梗死患者IMTmax差异存在显著性(P<0.05)。结论观察人群的CI-MT左侧大于右侧,提示在监测动脉粥样硬化发展与转归时有必要进行同侧别纵向比较;压力因素与生化因素对左右侧CIMT的影响结果保持一致。本结论尚需更大样本研究加以澄清。
Objective To address whether the side difference of the common carotid intima-medial thickness(CIMT)exists in human body,and observe the effects of hypertension,hyperlipidemia and diabetes mellitus.Methods With high frequency ultrasonography,we detected and measured 612 subjects without common carotid plaques for recording the maximum IMT(IMTmax)and average IMT(IMTave).The paired Student′s t test was used for the comparisons of the bilateral values for different groups classified by various risk factors,and P<0.05 was defined as significant.Results The left IMTave was larger than the right for all groups,in which P<0.05 only for the total subjects and the male,the healthy subjects under 30 years,hypertensive subjects and the male,hyperlipidemia subjects and the male as well.The left IMTmax was shown the similar changes with P<0.05 only for the female cardiac and cerebral infarction subjects.Conclusions The side difference of CIMT exists in human body,which indicates the necessity of comparison with the same lateral values in monitoring the atherosclerotic progress/regression.Blood pressure and biochemical factors affect the bilateral CIMT in accordance.These results need expanded data to confirm.
出处
《中华临床医师杂志（电子版）》
CAS
2012年第17期5140-5144,共5页
Chinese Journal of Clinicians(Electronic Edition)
基金
湖北省自然科学基金(2007ABA074)
关键词
动脉粥样硬化
超声检查
颈动脉内中膜厚度
Atherosclerosis
Ultrasonography
Common carotid intima-medial thickness
