摘要
目的建立家兔实验性耳痤疮模型,观察复方清肺饮颗粒治疗痤疮的作用。方法家兔左耳内侧涂浓煤焦油溶液0.5ml,1次/d,连续2周,建立耳痤疮动物模型。耳痤疮模型建立成功后将家兔随机分为清肺饮颗粒大、中、小剂量组、解毒痤疮丸组、模型实验组、正常对照组,分别灌饲清肺饮颗粒、解毒痤疮丸和蒸馏水2周,在造模前后及药物治疗前后,取家兔左右耳廓相同部位耳片,称重后计算耳片重量差值,光镜下观察耳廓组织病变。结果外涂煤焦油1周后,兔耳表面粗糙,增厚,可见粉刺、丘疹,组织学改变与人类痤疮相似;给药2周后,清肺饮颗粒不同剂量组和解毒痤疮丸组均可不同程度抑制痤疮模型家兔耳重量的增加,并明显改善耳痤疮炎性病理变化。结论清肺饮颗粒对家兔实验性耳痤疮有治疗作用,可用于痤疮的防治。
Objective To establish an experimental animal model of acne and investigate the therapeutic effect of Qingfeiyin granule for acne.Methods Experimental rabbit ear acne model was induced by external application of coal tar.Then the rabbits were randomly divided into high dose,medium dose and low dose Qingfeiyin granule group,Jie Du acne-pill group and negative control group,after that medicines above-mentioned were given respectively.The weight of the acne model ear was measured and histopathologic examination was performed by light microscope.Results One week after external application of coal tar,the surface of rabbit ears became rough and thick,comedones and papules could be seen there.The pathological changes of the lesions in rabbit ears were similar to that of human acne.Two weeks after medicine given,the comedones and papules were extinct in Qingfeiyin granule groups and Jie Du acne-pill group,and corresponding pathological changes were detected by light microscope.Conclusion Qingfeiyin granule has significant experimental anti-acne effects.
出处
《实用皮肤病学杂志》
2011年第2期105-108,共4页
Journal of Practical Dermatology
