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Separation of chiral drugs with sulfobutylether-β-cyclodextrin bycapillary zone electrophoresis 被引量:1

Separation of chiral drugs with sulfobutylether-β-cyclodextrin by capillary zone electrophoresis
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摘要 IntroductionChaedcyclodextrlnswerefirstIntroducedby几rabelforchlralseparationofamlnoacids,andthechargedCDcommonlyusednowdaysarecarboxymethyl-p-CD(CM-p-CD),p-CD-phosphate,Y-CD-phosphate,sulfobutylether-p-cyclodextrln(SBE-p-CD)etc.... Sulfobutylether-β-cyclodextrin(SBE-β-CD)was used as a chiral selector tor separatingten chlral drugs with resolution 1.2 by capillary zone electrophoresls(CZE), The backgroundelectrolylc solution comprised of 120 mmol/L Britton-Robinson buffer(BRB) containing1 ~10mmol/L SBE-β-CD with the pH value adjusted from 5.0-6.8. Five of the drugs were better resolvedthan those previously reported with neutral CDs.
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 1999年第1期39-42,共4页 中国化学快报(英文版)
关键词 Chiral SEPARATION sulfobutylether-β-cyclodextrin capillary zone electrophoresis anlsodamlne bencynonate ECONAZOLE ESMOLOL glycopynonate lobeline METHOXAMINE phenylephrine plnacidll TERAZOSIN Chiral separation sulfobutylether-β-cyclodextrin capillary zone electrophoresis anlsodamlne bencynonate econazole esmolol glycopynonate lobeline methoxamine phenylephrine plnacidll terazosin
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