摘要
SMADs是新近发观的一族细胞内信号传导蛋白,包括8个成员,即SMAD1～8。SMAD1、2、3、5和8是一类,它们被TGF-β受体或BMP受体激活而磷酸化,称为受体调节SMAD,传导TGF-β或BMP的信号。SMAD6和7是另一类,它们抑制受体调节SMAD传导信号。SMAD4是第2类,它是受体调节SMAD传导信号的伴侣。受体调节SMAD传导信号必须先与SMAD4结合形成异源复合物,才能进到核中,调节转录活动。本文简要介绍了各成员的特性及作用。
The review briefly discussed the recently identified intraceilular signeling proteins, SMAD family, which included 8 members, SMAD1 to SMAD8. The members of the SMAD proteins family can be categorized into three subgroups. SMAD1, 2, 3, 5, and 8 belong to the subgroup contained the SSXS motif at the C terminus which can be phosphorylated by the receptors of TGF-β or BMPs. Thus they are also called receptor-regulated SMADs, and mediate TGF-β or BMPs signals. The second subgroup is SMAD4 which is indispensable for the receptor regulated SMADs signaling. The receptor-regulated SMADs must form hetero-ohgorneric complex with SMAD4 before mediating the signals. While SMAD6 and SMAD7 belong to the third class that differ from the receptor-regulated subgroup as they lack the SSXS motif. They inhibit TGF-β superfamily mediating phosphorylation of receptor-regulated SMADs.
出处
《生物技术通讯》
CAS
1998年第3期198-204,共7页
Letters in Biotechnology
