摘要
何首乌浸膏提取物(简称PM2)增加小鼠脾重,对胸腺重量无影响;可提高脾脏PFC数量,并显著增强ConA诱导的胸腺及脾脏T淋巴细胞增殖反应,但对LPS诱导的脾脏B淋巴细胞增殖反应仅轻度增强。这些结果表明PM2对小鼠淋巴细胞具有选择性作用,以增强T细胞功能为主,进而间接增强B细胞对T依赖抗原的抗体应答。
The effect of water alcohol extract (PM2) from the rcot of Polygonum multiflorum Thunb on the murine immune function was investigated. Daily injection of the extract (PM2) at a dose of 25 mg/kg for 7 days induced an increase in spleen weight without any change in the thymus weight.PM2 ip at the dose range of 6.25-100 mg/ kg daily for 3-7 days increased significantly the ConA induced splenic T lymphocyte proliferation and thymus T lymphocyte proliferation, and increased slightly the LPS induced splenic B lymphocyte proliferation. PM2 given after the injection of SRBC caused a striking increase in splenic PFC value.These results demonstrated that PM2 has fairly potent effect on murine immune system, augmentingmmainly the T lymphocyte function, promoting antibody response of B lymphocyte to the T-cell-dependent antigen.
出处
《中药药理与临床》
CAS
CSCD
1989年第1期24-28,共5页
Pharmacology and Clinics of Chinese Materia Medica
